CD8/CD45RO T-cell infiltration in endoscopic biopsies of colorectal cancer predicts nodal metastasis and survival

Reliable prognostic markers based on biopsy specimens of colorectal cancer (CRC) are currently missing. We hypothesize that assessment of T-cell infiltration in biopsies of CRC may predict patient survival and TNM-stage before surgery. Pre-operative biopsies and matched resection specimens from 130...

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Bibliographic Details
Published in:Journal of translational medicine 2014-03, Vol.12 (1), p.81-81, Article 81
Main Authors: Koelzer, Viktor H, Lugli, Alessandro, Dawson, Heather, Hädrich, Marion, Berger, Martin D, Borner, Markus, Mallaev, Makhmudbek, Galván, José A, Amsler, Jennifer, Schnüriger, Beat, Zlobec, Inti, Inderbitzin, Daniel
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Biopsy - methods
CD8 Antigens - immunology
Colorectal cancer
Colorectal Neoplasms - immunology
Colorectal Neoplasms - pathology
Female
Humans
Leukocyte Common Antigens - immunology
Lymphatic Metastasis
Lymphocytes, Tumor-Infiltrating - immunology
Male
Medical research
Medical treatment
Medicine, Experimental
Middle Aged
Physiological aspects
Studies
Survival Analysis
T-Lymphocytes - immunology
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Summary:Reliable prognostic markers based on biopsy specimens of colorectal cancer (CRC) are currently missing. We hypothesize that assessment of T-cell infiltration in biopsies of CRC may predict patient survival and TNM-stage before surgery. Pre-operative biopsies and matched resection specimens from 130 CRC patients treated from 2002-2011 were included in this study. Whole tissue sections of biopsy material and primary tumors were immunostained for pancytokeratin and CD8 or CD45RO. Stromal (s) and intraepithelial (i) T-cell infiltrates were analyzed for prediction of patient survival as well as clinical and pathological TNM-stage of the primary tumor. CD8 T-cell infiltration in the preoperative biopsy was significantly associated with favorable overall survival (CD8i p = 0.0026; CD8s p = 0.0053) in patients with primary CRC independently of TNM-stage and postoperative therapy (HR [CD8i] = 0.55 (95% CI: 0.36-0.82), p = 0.0038; HR [CD8s] = 0.72 (95% CI: 0.57-0.9), p = 0.0049). High numbers of CD8i in the biopsy predicted earlier pT-stage (p 
ISSN:1479-5876
1479-5876
DOI:10.1186/1479-5876-12-81