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Cystitis : From Urothelial Cell Biology to Clinical Applications
Cystitis is a urinary bladder disease with many causes and symptoms. The severity of cystitis ranges from mild lower abdominal discomfort to life-threatening haemorrhagic cystitis. The course of disease is often chronic or recurrent. Although cystitis represents huge economical and medical burden th...
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| Published in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-10 |
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| container_end_page | 10 |
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| container_title | BioMed research international |
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| creator | Lee, Gilho Romih, Rok Zupančič, Daša |
| description | Cystitis is a urinary bladder disease with many causes and symptoms. The severity of cystitis ranges from mild lower abdominal discomfort to life-threatening haemorrhagic cystitis. The course of disease is often chronic or recurrent. Although cystitis represents huge economical and medical burden throughout the world and in many cases treatments are ineffective, the mechanisms of its origin and development as well as measures for effective treatment are still poorly understood. However, many studies have demonstrated that urothelial dysfunction plays a crucial role. In the present review we first discuss fundamental issues of urothelial cell biology, which is the core for comprehension of cystitis. Then we focus on many forms of cystitis, its current treatments, and advances in its research. Additionally we review haemorrhagic cystitis with one of the leading causative agents being chemotherapeutic drug cyclophosphamide and summarise its management strategies. At the end we describe an excellent and widely used animal model of cyclophosphamide induced cystitis, which gives researches the opportunity to get a better insight into the mechanisms involved and possibility to develop new therapy approaches. |
| doi_str_mv | 10.1155/2014/473536 |
| format | article |
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The severity of cystitis ranges from mild lower abdominal discomfort to life-threatening haemorrhagic cystitis. The course of disease is often chronic or recurrent. Although cystitis represents huge economical and medical burden throughout the world and in many cases treatments are ineffective, the mechanisms of its origin and development as well as measures for effective treatment are still poorly understood. However, many studies have demonstrated that urothelial dysfunction plays a crucial role. In the present review we first discuss fundamental issues of urothelial cell biology, which is the core for comprehension of cystitis. Then we focus on many forms of cystitis, its current treatments, and advances in its research. Additionally we review haemorrhagic cystitis with one of the leading causative agents being chemotherapeutic drug cyclophosphamide and summarise its management strategies. At the end we describe an excellent and widely used animal model of cyclophosphamide induced cystitis, which gives researches the opportunity to get a better insight into the mechanisms involved and possibility to develop new therapy approaches.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/473536</identifier><identifier>PMID: 24877098</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Antineoplastic Agents, Alkylating - therapeutic use ; Biology ; Bladder ; Cyclophosphamide ; Cyclophosphamide - therapeutic use ; Cystitis ; Cystitis - drug therapy ; Cystitis - metabolism ; Cystitis - pathology ; Cystitis - physiopathology ; Drug therapy ; Epidermal growth factor ; Excretory system ; Health aspects ; Hemorrhage - drug therapy ; Hemorrhage - metabolism ; Hemorrhage - pathology ; Hemorrhage - physiopathology ; Humans ; Membranes ; Permeability ; Plasma ; Proteins ; Review ; Rodents ; Smooth muscle ; Urine ; Urothelium - metabolism ; Urothelium - pathology ; Urothelium - physiopathology</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-10</ispartof><rights>Copyright © 2014 Gilho Lee et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Gilho Lee et al. Gilho Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Gilho Lee et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-22928317ac417cf4c638d230ecd4003ef4c9bf216232f6357e930d11428871e83</citedby><cites>FETCH-LOGICAL-c593t-22928317ac417cf4c638d230ecd4003ef4c9bf216232f6357e930d11428871e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1547924554/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1547924554?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24877098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Winder, Michael</contributor><creatorcontrib>Lee, Gilho</creatorcontrib><creatorcontrib>Romih, Rok</creatorcontrib><creatorcontrib>Zupančič, Daša</creatorcontrib><title>Cystitis : From Urothelial Cell Biology to Clinical Applications</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Cystitis is a urinary bladder disease with many causes and symptoms. The severity of cystitis ranges from mild lower abdominal discomfort to life-threatening haemorrhagic cystitis. The course of disease is often chronic or recurrent. Although cystitis represents huge economical and medical burden throughout the world and in many cases treatments are ineffective, the mechanisms of its origin and development as well as measures for effective treatment are still poorly understood. However, many studies have demonstrated that urothelial dysfunction plays a crucial role. In the present review we first discuss fundamental issues of urothelial cell biology, which is the core for comprehension of cystitis. Then we focus on many forms of cystitis, its current treatments, and advances in its research. Additionally we review haemorrhagic cystitis with one of the leading causative agents being chemotherapeutic drug cyclophosphamide and summarise its management strategies. At the end we describe an excellent and widely used animal model of cyclophosphamide induced cystitis, which gives researches the opportunity to get a better insight into the mechanisms involved and possibility to develop new therapy approaches.</description><subject>Antineoplastic Agents, Alkylating - therapeutic use</subject><subject>Biology</subject><subject>Bladder</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Cystitis</subject><subject>Cystitis - drug therapy</subject><subject>Cystitis - metabolism</subject><subject>Cystitis - pathology</subject><subject>Cystitis - physiopathology</subject><subject>Drug therapy</subject><subject>Epidermal growth factor</subject><subject>Excretory system</subject><subject>Health aspects</subject><subject>Hemorrhage - drug therapy</subject><subject>Hemorrhage - metabolism</subject><subject>Hemorrhage - pathology</subject><subject>Hemorrhage - physiopathology</subject><subject>Humans</subject><subject>Membranes</subject><subject>Permeability</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Review</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Urine</subject><subject>Urothelium - metabolism</subject><subject>Urothelium - pathology</subject><subject>Urothelium - physiopathology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFkc1PGzEQxa2qVUEpp55BK3FBoBSPv5cDIqygrYTUSzlbxutNjJx1sDet8t_jaGlauNQXj2Z-evabh9BnwF8AOD8nGNg5k5RT8Q7tEwpsKoDB-11N6R46yPkRl6NA4Fp8RHuEKSlxrfbRVbPJgx98ri6q2xSX1X2Kw8IFb0LVuBCqax9DnG-qIVZN8L23ZTBbrUIpBh_7_Al96EzI7uDlnqD725ufzbfp3Y-v35vZ3dTymg5TQmqiKEhjGUjbMSuoagnFzrYMY-pKp37oCAhCSScol66muAVgRCkJTtEJuhx1V-uHpWut64dkgl4lvzRpo6Px-vWk9ws9j780w4RAWcMEnbwIpPi0dnnQS59tsWh6F9dZAxdCcSkIFPT4DfoY16kv9grFZE0Y5-wvNTfBad93sbxrt6J6xojExQkWhTobKZtizsl1uy8D1tsI9TZCPUZY6KN_Xe7YP4EV4HQEFr5vzW__H7XDEXYFcZ3ZwUwySiV9Bh71qP8</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Lee, Gilho</creator><creator>Romih, Rok</creator><creator>Zupančič, Daša</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Cystitis : From Urothelial Cell Biology to Clinical Applications</title><author>Lee, Gilho ; Romih, Rok ; Zupančič, Daša</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-22928317ac417cf4c638d230ecd4003ef4c9bf216232f6357e930d11428871e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antineoplastic Agents, Alkylating - 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The severity of cystitis ranges from mild lower abdominal discomfort to life-threatening haemorrhagic cystitis. The course of disease is often chronic or recurrent. Although cystitis represents huge economical and medical burden throughout the world and in many cases treatments are ineffective, the mechanisms of its origin and development as well as measures for effective treatment are still poorly understood. However, many studies have demonstrated that urothelial dysfunction plays a crucial role. In the present review we first discuss fundamental issues of urothelial cell biology, which is the core for comprehension of cystitis. Then we focus on many forms of cystitis, its current treatments, and advances in its research. Additionally we review haemorrhagic cystitis with one of the leading causative agents being chemotherapeutic drug cyclophosphamide and summarise its management strategies. At the end we describe an excellent and widely used animal model of cyclophosphamide induced cystitis, which gives researches the opportunity to get a better insight into the mechanisms involved and possibility to develop new therapy approaches.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24877098</pmid><doi>10.1155/2014/473536</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content (ProQuest); Wiley Open Access |
| subjects | Antineoplastic Agents, Alkylating - therapeutic use Biology Bladder Cyclophosphamide Cyclophosphamide - therapeutic use Cystitis Cystitis - drug therapy Cystitis - metabolism Cystitis - pathology Cystitis - physiopathology Drug therapy Epidermal growth factor Excretory system Health aspects Hemorrhage - drug therapy Hemorrhage - metabolism Hemorrhage - pathology Hemorrhage - physiopathology Humans Membranes Permeability Plasma Proteins Review Rodents Smooth muscle Urine Urothelium - metabolism Urothelium - pathology Urothelium - physiopathology |
| title | Cystitis : From Urothelial Cell Biology to Clinical Applications |
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