Exhaled IL-8 in Systemic Lupus Erythematosus with and without Pulmonary Fibrosis

• Published in: Archivum Immunologiae et Therapiae Experimentalis 2014-06, Vol.62 (3), p.231-238
• Main Authors: Nielepkowicz-Goździńska, Agnieszka, Fendler, Wojciech, Robak, Ewa, Kulczycka-Siennicka, Lilianna, Górski, Paweł, Pietras, Tadeusz, Brzeziańska, Ewa, Antczak, Adam
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Breath Tests; Bronchoalveolar Lavage Fluid - immunology; Disease Progression; Exhalation; Female; Humans; Immunology; Interleukin-8 - metabolism; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - immunology; Male; Middle Aged; Original; Original Article; Pharmacology/Toxicology; Pulmonary Fibrosis - complications; Pulmonary Fibrosis - immunology; Spirometry; Young Adult
• ISSN: 0004-069X; 1661-4917
• DOI: 10.1007/s00005-014-0270-5

The purpose of this study is to evaluate the relationship between the concentration of interleukin-8 (IL-8) in exhaled breath condensate (EBC) and bronchoalveolar lavage fluid (BALF) with the disease activity score and pulmonary function of systemic lupus erythematosus (SLE) patients with and without pulmonary fibrosis. Thirty-four SLE patients and 31 healthy controls were enrolled and evaluated using high-resolution computed tomography (HRCT), pulmonary function tests, systemic lupus activity measure (SLAM), assessing BALF and EBC. IL-8 levels in BALF and EBC samples were measured with an enzyme-immunosorbent assay kit. The mean (±SEM) IL-8 concentrations in BALF and EBC were higher in SLE patients compared to healthy controls (34.84 ± 95.0 vs. 7.65 ± 21.22 pg/ml, p