Stem Cell Imaging: From Bench to Bedside

Although cellular therapies hold great promise for the treatment of human disease, results from several initial clinical trials have not shown a level of efficacy required for their use as a first line therapy. Here we discuss how in vivo molecular imaging has helped identify barriers to clinical tr...

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Bibliographic Details
Published in:Cell stem cell 2014-04, Vol.14 (4), p.431-444
Main Authors: Nguyen, Patricia K., Riegler, Johannes, Wu, Joseph C.
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - therapy
Cell Tracking - methods
Cell- and Tissue-Based Therapy
Humans
Molecular Imaging
Nervous System Diseases - diagnosis
Nervous System Diseases - therapy
Stem Cell Transplantation
Stem Cells - cytology
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Summary:Although cellular therapies hold great promise for the treatment of human disease, results from several initial clinical trials have not shown a level of efficacy required for their use as a first line therapy. Here we discuss how in vivo molecular imaging has helped identify barriers to clinical translation and potential strategies that may contribute to successful transplantation and improved outcomes, with a focus on cardiovascular and neurological diseases. We conclude with a perspective on the future role of molecular imaging in defining safety and efficacy for clinical implementation of stem cell therapies. This Review examines how in vivo molecular imaging has helped identify barriers to clinical translation of cell therapies and highlights potential strategies that may contribute to successful transplantation and improved outcomes.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2014.03.009