The role of EPH receptors in cancer-related epithelial-mesenchymal transition

Erythropoietin-producing hepatoma （EPH） receptors are considered the largest family of receptor tyrosine kinases and play key roles in physiological and pathologic processes in development and disease. EPH receptors are often overexpressed in human malignancies and are associated with poor prognosis...

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Bibliographic Details
Published in:Ai zheng 2014-05, Vol.33 (5), p.231-240
Main Authors: Li, Rui-Xin, Chen, Zi-Hua, Chen, Zhi-Kang
Format: Article
Language:English
Subjects:
Antineoplastic Agents
Cadherins
Epithelial-Mesenchymal Transition
Humans
Neoplasms
Receptor Protein-Tyrosine Kinases
Receptors, Eph Family - physiology
Review
Signal Transduction
上皮
促红细胞生成素
信号通路
受体酪氨酸激酶
恶性肿瘤
癌症治疗
转化
间质
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Summary:Erythropoietin-producing hepatoma （EPH） receptors are considered the largest family of receptor tyrosine kinases and play key roles in physiological and pathologic processes in development and disease. EPH receptors are often overexpressed in human malignancies and are associated with poor prognosis. However, the functions of EPH receptors in epithelial-mesenchymal transition （EMT） remain largely unknown. This review depicts the relationship between EPH receptors and the EMT marker E-cadherin as well as the crosstaik between EPH receptors and the signaling pathways involved EMT. Further discussion is focused on the clinical significance of EPH receptors as candidates for targeting in cancer therapeutics. Finally, we summarize how targeted inhibition of both EPH receptors and EMT-related signaling pathways represents a novel strategy for cancer treatment.
ISSN:1000-467X
1944-446X
DOI:10.5732/cjc.013.10108