Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

Regulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) is an enzyme acting as immune modulator through suppression of T-cell immunity. This study aims to investigate role of IDO in the microenvironment of HL. A total of 1...

Full description

Saved in:
Bibliographic Details
Published in:BMC cancer 2014-05, Vol.14 (1), p.335-335, Article 335
Main Authors: Choe, Ji-Young, Yun, Ji Yun, Jeon, Yoon Kyoung, Kim, Se Hoon, Park, Gyeongsin, Huh, Joo Ryoung, Oh, Sohee, Kim, Ji Eun
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Adolescent
Adult
Aged
Aged, 80 and over
Automation
Biomarkers, Tumor - analysis
Biopsy
Cancer
Cell Lineage
Child
Disease-Free Survival
Enzymes
Female
Hodgkin Disease - enzymology
Hodgkin Disease - mortality
Hodgkin Disease - pathology
Humans
Immunohistochemistry
Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis
Infections
Kaplan-Meier Estimate
Male
Medical prognosis
Middle Aged
Multivariate analysis
Pathology
Patients
Proportional Hazards Models
Retrospective Studies
Software
Statistical analysis
Stromal Cells - enzymology
Stromal Cells - pathology
Studies
Time Factors
Tumor Microenvironment
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Regulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) is an enzyme acting as immune modulator through suppression of T-cell immunity. This study aims to investigate role of IDO in the microenvironment of HL. A total of 121 cases of HL were enrolled to do immunohistochemistry for IDO, CD163, CD68, CD4, CD8, and FoxP3. Positivity was evaluated from area fractions or numbers of positive cells using automated image analyzer. Correlations between IDO expression and various cellular infiltrates and clinicopathologic parameters were examined and survival analyses were performed. IDO was expressed in histiocytes, dendritic cells and some endothelial cells with variable degrees, but not in tumor cells. IDO positive cells were more frequently found in mixed cellularity type than other histologic types, and in cases with EBV+, high Ann Arbor stages, B symptoms, and high IPS (all p 
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-14-335