Original Design of Fluorescent Ligands by Fusing BODIPY and Melatonin Neurohormone

An original design and synthesis of fluorescent ligands for melatonin receptor studies is presented and consists in the fusion of the endogenous ligand with the fluorescent BODIPY core. Probes I–IV show high affinities for MT1 and MT2 melatonin receptors and exhibit fluorescence properties compatibl...

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Bibliographic Details
Published in:ACS medicinal chemistry letters 2014-02, Vol.5 (2), p.158-161
Main Authors: Thireau, Jérémy, Marteaux, Justine, Delagrange, Philippe, Lefoulon, Francois, Dufourny, Laurence, Guillaumet, Gérald, Suzenet, Franck
Format: Article
Language:English
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Life Sciences
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Summary:An original design and synthesis of fluorescent ligands for melatonin receptor studies is presented and consists in the fusion of the endogenous ligand with the fluorescent BODIPY core. Probes I–IV show high affinities for MT1 and MT2 melatonin receptors and exhibit fluorescence properties compatible with cell observation.
ISSN:1948-5875
1948-5875
DOI:10.1021/ml4004155