Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms

Highlights ► We examine how a positive outlook changes under acute stress. ► We also quantify acute stress-induced change in pro-inflammatory interleukin-1β. ► Loss of a positive outlook is associated with greater pro-inflammatory reactivity. ► Greater pro-inflammatory reactivity predicts future dep...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2012-02, Vol.26 (2), p.346-352
Main Authors: Aschbacher, K, Epel, E, Wolkowitz, O.M, Prather, A.A, Puterman, E, Dhabhar, F.S
Format: Article
Language:English
Subjects:
Acute stress
Affect - physiology
Aged
Allergy and Immunology
Cytokine
Depression - etiology
Depression - immunology
Depression - psychology
Depressive symptoms
Female
Humans
Inflammation - physiopathology
Inflammation - psychology
Interleukin-1 beta
Interleukin-1beta - blood
Interleukin-6 - blood
Middle Aged
Positive affect
Pro-inflammatory
Psychiatric Status Rating Scales
Psychiatry
Reactivity
Stress, Psychological - immunology
Stress, Psychological - psychology
Time Factors
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Summary:Highlights ► We examine how a positive outlook changes under acute stress. ► We also quantify acute stress-induced change in pro-inflammatory interleukin-1β. ► Loss of a positive outlook is associated with greater pro-inflammatory reactivity. ► Greater pro-inflammatory reactivity predicts future depressive symptom increases. ► These data suggest a need for integrative approaches to treatment.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.10.010