AMPD1 rs17602729 is associated with physical performance of sprint and power in elite Lithuanian athletes

The C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair exercise capacity. The aim of the present study was twofold: (1) to determine the C34T A...

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Bibliographic Details
Published in:BMC genetics 2014-05, Vol.15 (1), p.58-58
Main Authors: Ginevičienė, Valentina, Jakaitienė, Audronė, Pranculis, Aidas, Milašius, Kazys, Tubelis, Linas, Utkus, Algirdas
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
AMP Deaminase - genetics
Anthropometry
Athletes
Athletic Performance
Equilibrium
Female
Frequency distribution
Gene expression
Gene Frequency
Genetics
Genotype
Humans
Lithuania
Male
Muscle Strength - genetics
Musculoskeletal system
Mutation
Physical Endurance - genetics
Polymorphism, Genetic
Software
Standard deviation
Studies
Young Adult
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Summary:The C34T genetic polymorphism (rs17602729) in the AMPD1 gene, encoding the skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD1), is a common polymorphism among Caucasians that can impair exercise capacity. The aim of the present study was twofold: (1) to determine the C34T AMPD1 allele/genotype frequency distributions in Lithuanian athletes (n = 204, stratified into three groups: endurance, sprint/power and mixed) and compare them with the allele/genotype frequency distributions in randomly selected healthy Lithuanian non-athletes (n = 260) and (2) to compare common anthropometric measurements and physical performance phenotypes between the three groups of athletes depending on their AMPD1 genotype. The results of our study indicate that the frequency of the AMPD1 TT genotype was 2.4% in the control group, while it was absent in the athlete group. There were significantly more sprint/power-orientated athletes with the CC genotype (86.3%) compared with the endurance-orientated athletes (72.9%), mixed athletes (67.1%), and controls (74.2%). We determined that the AMPD1 C34T polymorphism is not associated with aerobic muscle performance phenotype (VO2max). For CC genotype the short-term explosive muscle power value (based on Vertical Jump test) of athletes from the sprint/power group was significantly higher than that of the endurance group athletes (P 
ISSN:1471-2156
1471-2156
DOI:10.1186/1471-2156-15-58