Assessment of Acute Oral and Dermal Toxicity of 2 Ethyl-Carbamates with Activity against Rhipicephalus microplus in Rats

The acute oral and dermal toxicity of two new ethyl-carbamates (ethyl-4-bromophenyl-carbamate and ethyl-4-chlorophenyl-carbamate) with ixodicide activity was determined in rats. The oral LD50 of each carbamate was 300 to 2000 mg/kg, and the dermal LD50 of each carbamate was >5000 mg/kg. Clinicall...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-10
Main Authors: Prado-Ochoa, María Guadalupe, Gutiérrez-Amezquita, Ricardo Alfonso, Abrego-Reyes, Víctor Hugo, Velázquez-Sánchez, Ana María, Muñoz-Guzmán, Marco Antonio, Ramírez-Noguera, Patricia, Angeles, Enrique, Alba-Hurtado, Fernando
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Carbamates
Creatinine - blood
Liver - drug effects
Male
Medical research
Medicine, Experimental
Molecular weight
Rats
Rhipicephalus
Rhipicephalus - drug effects
Rodents
Skin - drug effects
Studies
Ticks
Toxicity
Urethane - analogs & derivatives
Urethane - pharmacology
Urethane - toxicity
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Summary:The acute oral and dermal toxicity of two new ethyl-carbamates (ethyl-4-bromophenyl-carbamate and ethyl-4-chlorophenyl-carbamate) with ixodicide activity was determined in rats. The oral LD50 of each carbamate was 300 to 2000 mg/kg, and the dermal LD50 of each carbamate was >5000 mg/kg. Clinically, the surviving rats that had received oral doses of each carbamate showed decreased weight gain (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/956456