Bacterial infection after liver transplantation

Infectious complications are major causes of morbidity and mortality after liver transplantation,despite recent advances in the transplant field.Bacteria,fungi,viruses and parasites can cause infection before and after transplantation.Among them,bacterial infections are predominant during the first...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-05, Vol.20 (20), p.6211-6220
Main Author: Kim, Sang Il
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Bacteremia - complications
Bacterial
Bacterial Infections - complications
Colitis - complications
Colitis - microbiology
Communicable Disease Control
Drug Resistance, Multiple, Bacterial - drug effects
Humans
Immunosuppressive Agents - adverse effects
Incidence
infection
Intraabd
Liver
Liver Diseases - complications
Liver Diseases - surgery
Liver Transplantation - adverse effects
Pneumonia - complications
Pneumonia - microbiology
Risk Factors
Topic Highlight
transplantation
Urinary Tract Infections - complications
Urinary Tract Infections - microbiology
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Summary:Infectious complications are major causes of morbidity and mortality after liver transplantation,despite recent advances in the transplant field.Bacteria,fungi,viruses and parasites can cause infection before and after transplantation.Among them,bacterial infections are predominant during the first two months posttransplantation and affect patient and graft survival.They might cause surgical site infections,including deep intra-abdominal infections,bacteremia,pneumonia,catheter-related infections and urinary tract infections.The risk factors for bacterial infections differ between the periods after transplant,and between centers.Recently,the emergence of multi-drug resistant bacteria is great concern in liver transplant(LT)patients.The instructive data about effects of infections with extended-spectrum beta lactamase producing bacteria,carbapenem-resistant gram-negative bacteria,and glycopeptide-resistant gram-positive bacteria were reported on a center-by-center basis.To prevent posttransplant bacterial infections,proper strategies need to be established based upon center-specific data and evidence from well-controlled studies.This article reviewed the recent epidemiological data,risk factors for each type of infections and important clinical issues in bacterial infection after LT.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i20.6211