Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract

We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extr...

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Bibliographic Details
Published in:Bioscience of Microbiota, Food and Health Food and Health, 2012, Vol.31(1), pp.1-6
Main Authors: KIM, Yoon Hee, IDA, Megumi, YAMASHITA, Shuya, TSUKAMOTO, Shuntaro, KUMAZOE, Motofumi, SUMIDA, Mami, KAWAKAMI, Mitsuo, YAMADA, Koji, TACHIBANA, Hirofumi
Format: Article
Language:English
Subjects:
atopic dermatitis
histamine
Kakrol
Momordica
Momordica dioica Roxb
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Summary:We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on development of atopic dermatitis-like lesions in picryl chloride-treated NC/Nga mice. The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum. These results indicate that the water extract of kakrol flesh might have therapeutic potential for allergic responses in vitro and in vivo.
ISSN:2186-3342
2186-6953
2186-3342
DOI:10.12938/bmfh.31.1