Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract

We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extr...

Full description

Saved in:
Bibliographic Details
Published in:Bioscience of Microbiota, Food and Health Food and Health, 2012, Vol.31(1), pp.1-6
Main Authors: KIM, Yoon Hee, IDA, Megumi, YAMASHITA, Shuya, TSUKAMOTO, Shuntaro, KUMAZOE, Motofumi, SUMIDA, Mami, KAWAKAMI, Mitsuo, YAMADA, Koji, TACHIBANA, Hirofumi
Format: Article
Language:English
Subjects:
atopic dermatitis
histamine
Kakrol
Momordica
Momordica dioica Roxb
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c5541-2ca50d7ea964987fc43a212d374048bd13f5d3ee8b03fea1601268018d29b4683
container_end_page 6
container_issue 1
container_start_page 1
container_title Bioscience of Microbiota, Food and Health
container_volume 31
creator KIM, Yoon Hee
IDA, Megumi
YAMASHITA, Shuya
TSUKAMOTO, Shuntaro
KUMAZOE, Motofumi
SUMIDA, Mami
KAWAKAMI, Mitsuo
YAMADA, Koji
TACHIBANA, Hirofumi
description We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on development of atopic dermatitis-like lesions in picryl chloride-treated NC/Nga mice. The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum. These results indicate that the water extract of kakrol flesh might have therapeutic potential for allergic responses in vitro and in vivo.
doi_str_mv 10.12938/bmfh.31.1
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4034278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1534834999</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5541-2ca50d7ea964987fc43a212d374048bd13f5d3ee8b03fea1601268018d29b4683</originalsourceid><addsrcrecordid>eNpVUNFKAzEQDKKoqC9-wT2qcDXJ5q65F6FIq6IiiD6HXG7TRnMXTa5S_97WStV92FmYYWYZQo4ZHTBegTyvWzsbABuwLbLPmSxzAMG3_9x75CilF7qckhalgF2yx0UFJQjYJ5NR17t85D3GqTPZ2Fo0fcqCzW71aww-O7kPbYiNMzprXFjBY1jUg9Ns4jHNsvGij9r0h2THap_w6AcPyPNk_HR5nd89XN1cju5yUxSC5dzogjZD1FUpKjm0RoDmjDcwFFTIumFgiwYQZU3BomYlZbyUlMmGV7UoJRyQi7Xv27xusTHYLeO9eouu1fFTBe3Uf6ZzMzUNH0rQZRPDlcHJj0EM73NMvWpdMui97jDMk2IFCAmiqqql9GwtNTGkFNFuYhhV392rVfcKmGK_j72kXk9xI9Wxd8bjr3K92IYwMx0VdvAFSiaLNg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1534834999</pqid></control><display><type>article</type><title>Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract</title><source>Open Access: PubMed Central</source><creator>KIM, Yoon Hee ; IDA, Megumi ; YAMASHITA, Shuya ; TSUKAMOTO, Shuntaro ; KUMAZOE, Motofumi ; SUMIDA, Mami ; KAWAKAMI, Mitsuo ; YAMADA, Koji ; TACHIBANA, Hirofumi</creator><creatorcontrib>KIM, Yoon Hee ; IDA, Megumi ; YAMASHITA, Shuya ; TSUKAMOTO, Shuntaro ; KUMAZOE, Motofumi ; SUMIDA, Mami ; KAWAKAMI, Mitsuo ; YAMADA, Koji ; TACHIBANA, Hirofumi</creatorcontrib><description>We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on development of atopic dermatitis-like lesions in picryl chloride-treated NC/Nga mice. The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum. These results indicate that the water extract of kakrol flesh might have therapeutic potential for allergic responses in vitro and in vivo.</description><identifier>ISSN: 2186-3342</identifier><identifier>ISSN: 2186-6953</identifier><identifier>EISSN: 2186-3342</identifier><identifier>DOI: 10.12938/bmfh.31.1</identifier><identifier>PMID: 24936343</identifier><language>eng</language><publisher>BMFH Press</publisher><subject>atopic dermatitis ; histamine ; Kakrol ; Momordica ; Momordica dioica Roxb</subject><ispartof>Bioscience of Microbiota, Food and Health, 2012, Vol.31(1), pp.1-6</ispartof><rights>2012 by BMFH Press</rights><rights>Bioscience of Microbiota, Food and Health 2012</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5541-2ca50d7ea964987fc43a212d374048bd13f5d3ee8b03fea1601268018d29b4683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034278/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034278/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>KIM, Yoon Hee</creatorcontrib><creatorcontrib>IDA, Megumi</creatorcontrib><creatorcontrib>YAMASHITA, Shuya</creatorcontrib><creatorcontrib>TSUKAMOTO, Shuntaro</creatorcontrib><creatorcontrib>KUMAZOE, Motofumi</creatorcontrib><creatorcontrib>SUMIDA, Mami</creatorcontrib><creatorcontrib>KAWAKAMI, Mitsuo</creatorcontrib><creatorcontrib>YAMADA, Koji</creatorcontrib><creatorcontrib>TACHIBANA, Hirofumi</creatorcontrib><title>Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract</title><title>Bioscience of Microbiota, Food and Health</title><description>We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on development of atopic dermatitis-like lesions in picryl chloride-treated NC/Nga mice. The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum. These results indicate that the water extract of kakrol flesh might have therapeutic potential for allergic responses in vitro and in vivo.</description><subject>atopic dermatitis</subject><subject>histamine</subject><subject>Kakrol</subject><subject>Momordica</subject><subject>Momordica dioica Roxb</subject><issn>2186-3342</issn><issn>2186-6953</issn><issn>2186-3342</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpVUNFKAzEQDKKoqC9-wT2qcDXJ5q65F6FIq6IiiD6HXG7TRnMXTa5S_97WStV92FmYYWYZQo4ZHTBegTyvWzsbABuwLbLPmSxzAMG3_9x75CilF7qckhalgF2yx0UFJQjYJ5NR17t85D3GqTPZ2Fo0fcqCzW71aww-O7kPbYiNMzprXFjBY1jUg9Ns4jHNsvGij9r0h2THap_w6AcPyPNk_HR5nd89XN1cju5yUxSC5dzogjZD1FUpKjm0RoDmjDcwFFTIumFgiwYQZU3BomYlZbyUlMmGV7UoJRyQi7Xv27xusTHYLeO9eouu1fFTBe3Uf6ZzMzUNH0rQZRPDlcHJj0EM73NMvWpdMui97jDMk2IFCAmiqqql9GwtNTGkFNFuYhhV392rVfcKmGK_j72kXk9xI9Wxd8bjr3K92IYwMx0VdvAFSiaLNg</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>KIM, Yoon Hee</creator><creator>IDA, Megumi</creator><creator>YAMASHITA, Shuya</creator><creator>TSUKAMOTO, Shuntaro</creator><creator>KUMAZOE, Motofumi</creator><creator>SUMIDA, Mami</creator><creator>KAWAKAMI, Mitsuo</creator><creator>YAMADA, Koji</creator><creator>TACHIBANA, Hirofumi</creator><general>BMFH Press</general><general>Bioscience of Microbiota, Food and Health</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract</title><author>KIM, Yoon Hee ; IDA, Megumi ; YAMASHITA, Shuya ; TSUKAMOTO, Shuntaro ; KUMAZOE, Motofumi ; SUMIDA, Mami ; KAWAKAMI, Mitsuo ; YAMADA, Koji ; TACHIBANA, Hirofumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5541-2ca50d7ea964987fc43a212d374048bd13f5d3ee8b03fea1601268018d29b4683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>atopic dermatitis</topic><topic>histamine</topic><topic>Kakrol</topic><topic>Momordica</topic><topic>Momordica dioica Roxb</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM, Yoon Hee</creatorcontrib><creatorcontrib>IDA, Megumi</creatorcontrib><creatorcontrib>YAMASHITA, Shuya</creatorcontrib><creatorcontrib>TSUKAMOTO, Shuntaro</creatorcontrib><creatorcontrib>KUMAZOE, Motofumi</creatorcontrib><creatorcontrib>SUMIDA, Mami</creatorcontrib><creatorcontrib>KAWAKAMI, Mitsuo</creatorcontrib><creatorcontrib>YAMADA, Koji</creatorcontrib><creatorcontrib>TACHIBANA, Hirofumi</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioscience of Microbiota, Food and Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, Yoon Hee</au><au>IDA, Megumi</au><au>YAMASHITA, Shuya</au><au>TSUKAMOTO, Shuntaro</au><au>KUMAZOE, Motofumi</au><au>SUMIDA, Mami</au><au>KAWAKAMI, Mitsuo</au><au>YAMADA, Koji</au><au>TACHIBANA, Hirofumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract</atitle><jtitle>Bioscience of Microbiota, Food and Health</jtitle><date>2012-01-01</date><risdate>2012</risdate><volume>31</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2186-3342</issn><issn>2186-6953</issn><eissn>2186-3342</eissn><abstract>We examined the inhibitory effect of the extract of kakrol extracted by 3 types of solvent (water, 50% and 100% ethanol) on histamine release in human basophilic KU812 cells. The water extract of kakrol flesh showed the strongest inhibitory effect on histamine release as compared with the other extracts. Therefore, we evaluated whether water extract of kakrol flesh had a suppressive effect on development of atopic dermatitis-like lesions in picryl chloride-treated NC/Nga mice. The dietary kakrol flesh water extract alleviated the development of skin lesions in ears accompanied by lower IgE levels and inflammatory cytokines levels in serum. These results indicate that the water extract of kakrol flesh might have therapeutic potential for allergic responses in vitro and in vivo.</abstract><pub>BMFH Press</pub><pmid>24936343</pmid><doi>10.12938/bmfh.31.1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2186-3342
ispartof Bioscience of Microbiota, Food and Health, 2012, Vol.31(1), pp.1-6
issn 2186-3342
2186-6953
2186-3342
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4034278
source Open Access: PubMed Central
subjects atopic dermatitis
histamine
Kakrol
Momordica
Momordica dioica Roxb
title Anti-Allergic Effects of Kakrol (Momordica dioica Roxb.) Flesh Extract
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T03%3A15%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-Allergic%20Effects%20of%20Kakrol%20(Momordica%20dioica%20Roxb.)%20Flesh%20Extract&rft.jtitle=Bioscience%20of%20Microbiota,%20Food%20and%20Health&rft.au=KIM,%20Yoon%20Hee&rft.date=2012-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.epage=6&rft.pages=1-6&rft.issn=2186-3342&rft.eissn=2186-3342&rft_id=info:doi/10.12938/bmfh.31.1&rft_dat=%3Cproquest_pubme%3E1534834999%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5541-2ca50d7ea964987fc43a212d374048bd13f5d3ee8b03fea1601268018d29b4683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1534834999&rft_id=info:pmid/24936343&rfr_iscdi=true