Birth weight and other perinatal characteristics and childhood leukemia in California

Abstract Aims. We conducted a large registry-based study in California to investigate the association of perinatal factors and childhood leukemia with analysis of two major subtypes, acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). Methods. We linked California cancer and birth reg...

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Bibliographic Details
Published in:Cancer epidemiology 2012-12, Vol.36 (6), p.e359-e365
Main Authors: Oksuzyan, S, Crespi, C.M, Cockburn, M, Mezei, G, Kheifets, L
Format: Article
Language:English
Subjects:
Adolescent
Birth order
Birth Weight
California - epidemiology
Cancer
Case-Control Studies
Child
Child, Preschool
Childhood leukemia
Epidemiology
Female
Health risk assessment
Hematology, Oncology and Palliative Medicine
Humans
Infant
Infant, Newborn
Internal Medicine
Leukemia
Male
Parental age
Perinatal factors
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Pregnancy
Pregnancy complications
Registries
Studies
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Summary:Abstract Aims. We conducted a large registry-based study in California to investigate the association of perinatal factors and childhood leukemia with analysis of two major subtypes, acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). Methods. We linked California cancer and birth registries to obtain information on 5788 cases and 5788 controls matched on age and sex (1:1). We examined the association of birth weight, gestational age, birth and pregnancy order, parental ages, and specific conditions during pregnancy and risk of total leukemia, ALL and AML using conditional logistic regression, with adjustment for potential confounders. Results. The odds ratio (OR) per 1000 g increase in birth weight was 1.11 for both total leukemia and ALL. The OR were highest for babies weighing ≥4500 g with reference
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2012.08.002