Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging

Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are th...

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Bibliographic Details
Published in:Aging and disease 2014-06, Vol.5 (3), p.212-217
Main Authors: Prasad, Chandan, Imrhan, Victorine, Marotta, Francesco, Juma, Shanil, Vijayagopal, Parakat
Format: Article
Language:English
Subjects:
Review
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Summary:Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2014.0500212