Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent vehicle for poorly aqueous soluble drugs, which are otherwise difficult to formu...

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Bibliographic Details
Published in:AAPS PharmSciTech 2014-06, Vol.15 (3), p.694-708
Main Authors: Ganta, Srinivas, Talekar, Meghna, Singh, Amit, Coleman, Timothy P., Amiji, Mansoor M.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Chemistry, Pharmaceutical
Contrast Media
Diagnostic Imaging - methods
Drug Carriers
Emulsions
Humans
Lipids - chemistry
Lipids - toxicity
Molecular Targeted Therapy
Nanomedicine
Nanoparticles
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - metabolism
Pharmacology/Toxicology
Pharmacy
Radiopharmaceuticals
Review
Review Article
Technology, Pharmaceutical - methods
Theme: Translational Application of Nano Delivery Systems: Emerging Cancer Therapy
Translational Medical Research
Tumor Microenvironment
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Summary:Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent vehicle for poorly aqueous soluble drugs, which are otherwise difficult to formulate in conventional dosage forms. Nanoemulsions are submicron emulsions composed of generally regarded as safe grade excipients. Particle size at the nanoscale and larger surface area lead to some very interesting physical properties that can be exploited to overcome anatomical and physiological barriers associated in drug delivery to the complex diseases such as cancer. Along these lines, nanoemulsions have been engineered with specific attributes such as size, surface charge, prolonged blood circulation, target specific binding ability, and imaging capability. These attributes can be tuned to assist in delivering drug/imaging agents to the specific site of interest, based on active and passive targeting mechanisms. This review focuses on the current state of nanoemulsions in the translational research and its role in targeted cancer therapy. In addition, the production, physico-chemical characterization, and regulatory aspects of nanoemulsion are addressed.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-014-0088-9