Resting-state slow wave power, healthy aging and cognitive performance

Cognitive functions and spontaneous neural activity show significant changes over the life-span, but the interrelations between age, cognition and resting-state brain oscillations are not well understood. Here, we assessed performance on the Trail Making Test and resting-state magnetoencephalographi...

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Bibliographic Details
Published in:Scientific reports 2014-05, Vol.4 (1), p.5101-5101, Article 5101
Main Authors: Vlahou, Eleni L., Thurm, Franka, Kolassa, Iris-Tatjana, Schlee, Winfried
Format: Article
Language:English
Subjects:
631/378/2612
631/378/2649
Adolescent
Adult
Aged
Aged, 80 and over
Aging
Aging - physiology
Brain - physiology
Cognition
Cognition - physiology
Cognitive ability
Electric currents
Executive function
Female
Healthy Volunteers
Humanities and Social Sciences
Humans
Magnetoencephalography
Male
Middle Aged
multidisciplinary
Oscillations
Science
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Summary:Cognitive functions and spontaneous neural activity show significant changes over the life-span, but the interrelations between age, cognition and resting-state brain oscillations are not well understood. Here, we assessed performance on the Trail Making Test and resting-state magnetoencephalographic (MEG) recordings from 53 healthy adults (18–89 years old) to investigate associations between age-dependent changes in spontaneous oscillatory activity and cognitive performance. Results show that healthy aging is accompanied by a marked and linear decrease of resting-state activity in the slow frequency range (0.5–6.5 Hz). The effects of slow wave power on cognitive performance were expressed as interactions with age: For older (>54 years), but not younger participants, enhanced delta and theta power in temporal and central regions was positively associated with perceptual speed and executive functioning. Consistent with previous work, these findings substantiate further the important role of slow wave oscillations in neurocognitive function during healthy aging.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep05101