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Resting-state slow wave power, healthy aging and cognitive performance
Cognitive functions and spontaneous neural activity show significant changes over the life-span, but the interrelations between age, cognition and resting-state brain oscillations are not well understood. Here, we assessed performance on the Trail Making Test and resting-state magnetoencephalographi...
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Published in: | Scientific reports 2014-05, Vol.4 (1), p.5101-5101, Article 5101 |
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description | Cognitive functions and spontaneous neural activity show significant changes over the life-span, but the interrelations between age, cognition and resting-state brain oscillations are not well understood. Here, we assessed performance on the Trail Making Test and resting-state magnetoencephalographic (MEG) recordings from 53 healthy adults (18–89 years old) to investigate associations between age-dependent changes in spontaneous oscillatory activity and cognitive performance. Results show that healthy aging is accompanied by a marked and linear decrease of resting-state activity in the slow frequency range (0.5–6.5 Hz). The effects of slow wave power on cognitive performance were expressed as interactions with age: For older (>54 years), but not younger participants, enhanced delta and theta power in temporal and central regions was positively associated with perceptual speed and executive functioning. Consistent with previous work, these findings substantiate further the important role of slow wave oscillations in neurocognitive function during healthy aging. |
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subjects | 631/378/2612 631/378/2649 Adolescent Adult Aged Aged, 80 and over Aging Aging - physiology Brain - physiology Cognition Cognition - physiology Cognitive ability Electric currents Executive function Female Healthy Volunteers Humanities and Social Sciences Humans Magnetoencephalography Male Middle Aged multidisciplinary Oscillations Science |
title | Resting-state slow wave power, healthy aging and cognitive performance |
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