Revisiting morphine-augmented hepatobiliary imaging for diagnosing acute cholecystitis: the potential pitfall of high false positive rate

• Published in: Abdominal imaging 2014-06, Vol.39 (3), p.467-471
• Main Authors: Hung, Bor-Tau, Traylor, Katie S., Wong, Ching-yee Oliver
• Format: Article
• Language: English
• Subjects: Analgesics, Opioid - administration & dosage; Biliary Tract - diagnostic imaging; Cholecystitis, Acute - diagnostic imaging; Diagnosis, Differential; False Positive Reactions; Female; Gallbladder - diagnostic imaging; Gastroenterology; Hepatology; Humans; Image Enhancement - methods; Imaging; Liver - diagnostic imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Morphine - administration & dosage; Radiology; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Technetium
• ISSN: 0942-8925; 2366-004X; 1432-0509; 2366-0058
• DOI: 10.1007/s00261-013-0067-8

Purpose The aim of this retrospective study was to investigate the efficacy of morphine-augmented hepatobiliary imaging (MAHBI) for diagnosing acute cholecystitis (AC). Methods Sixty-eight patients (Male:Female = 36:32, age = 54 ± 17 years) referred for diagnosis of AC by 30-min post-morphine MAHBI after the standard 1-h imaging were recruited. Non-visualization of gallbladder on 30-min post-morphine images by visual analysis was considered positive. Final diagnosis of pathological examination for all patients was used as the gold standard. Results There was significant correlation of AC and MAHBI ( p