Treatment options for patients with large cell neuroendocrine carcinoma of the lung

Large cell neuroendocrine carcinoma (LCNEC) of the lung is categorized as a variant of large cell carcinomas, and LCNEC tumors display biological behaviors resembling those of small cell lung carcinomas and features of high-grade neuroendocrine tumors. Because patients with LCNEC have a poor prognos...

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Bibliographic Details
Published in:General thoracic and cardiovascular surgery 2014-06, Vol.62 (6), p.351-356
Main Authors: Iyoda, Akira, Makino, Takashi, Koezuka, Satoshi, Otsuka, Hajime, Hata, Yoshinobu
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Cancer
Carcinoma, Large Cell - drug therapy
Carcinoma, Large Cell - pathology
Carcinoma, Large Cell - surgery
Carcinoma, Neuroendocrine - drug therapy
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - surgery
Cardiac Surgery
Cardiology
Chemotherapy
Combined Modality Therapy
Current Topics Review
Current Topics Review Article
Humans
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Medical prognosis
Medicine
Medicine & Public Health
Neuroendocrine tumors
Prognosis
Response rates
Surgery
Surgical Oncology
Thoracic Surgery
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Summary:Large cell neuroendocrine carcinoma (LCNEC) of the lung is categorized as a variant of large cell carcinomas, and LCNEC tumors display biological behaviors resembling those of small cell lung carcinomas and features of high-grade neuroendocrine tumors. Because patients with LCNEC have a poor prognosis, surgery alone is not sufficient. Multimodality therapies, including adjuvant chemotherapy, appear promising for improved prognosis in patients with LCNEC. In this review article, we discuss treatment options for patients with LCNEC of the lung.
ISSN:1863-6705
1863-6713
DOI:10.1007/s11748-014-0379-9