Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys

Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol (control) implants (n = 6/group) beginning prepub...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2014-06, Vol.306 (11), p.E1292-E1304
Main Authors: McGee, W K, Bishop, C V, Pohl, C R, Chang, R J, Marshall, J C, Pau, F K, Stouffer, R L, Cameron, J L
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adiposity - physiology
Aging - physiology
Animals
Body fat
Body Weight - physiology
Cholesterol
Cholesterol - administration & dosage
Cholesterol - pharmacology
Diet, High-Fat
Drug Implants
Enzyme-Linked Immunosorbent Assay
Female
Glucose Tolerance Test
Gonadotropin-Releasing Hormone - blood
Hormones
Hyperandrogenism - complications
Hyperandrogenism - physiopathology
Luteinizing Hormone - blood
Macaca mulatta
Metabolism - physiology
Motor Activity
Neurosecretory Systems - physiology
Obesity
Ovary - anatomy & histology
Ovary - physiology
Physiology
Polycystic ovary syndrome
Reproduction - physiology
Testosterone - blood
Testosterone - deficiency
Testosterone - pharmacology
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Summary:Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol (control) implants (n = 6/group) beginning prepubertally. As previously reported, T-treated animals had increased neuroendocrine drive to the reproductive axis [increased luteinizing hormone (LH) pulse frequency] at 5 yr, without remarkable changes in ovarian or metabolic features. To examine the combined effects of T and obesity, at 5.5 yr (human equivalent age: 17 yr), monkeys were placed on a high-calorie, high-fat diet typical of Western cultures [Western style diet (WSD)], which increased body fat from
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00310.2013