Double-stranded DNA in exosomes： a novel biomarker in cancer detection

• Published in: Cell research 2014-06, Vol.24 (6), p.766-769
• Main Authors: Thakur, Basant Kumar, Zhang, Haiying, Becker, Annette, Matei, Irina, Huang, Yujie, Costa-Silva, Bruno, Zheng, Yan, Hoshino, Ayuko, Brazier, Helene, Xiang, Jenny, Williams, Caitlin, Rodriguez-Barrueco, Ruth, Silva, Jose M, Zhang, Weijia, Hearn, Stephen, Elemento, Olivier, Paknejad, Navid, Manova-Todorova, Katia, Welte, Karl, Bromberg, Jacqueline, Peinado, Héctor, Lyden, David
• Format: Article
• Language: English
• Subjects: 631/337; 631/67/1857; Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Cell Biology; Cell Line, Tumor; DNA - metabolism; Early Detection of Cancer; Exosomes - genetics; Exosomes - metabolism; HCT116 Cells; Humans; K562 Cells; Letter to the Editor; Life Sciences; Mice; microRNA; Neoplasms - diagnosis; Neoplasms - metabolism; ssDNA; 单链DNA; 双链DNA; 生物分子; 生物标记物; 癌症检测; 细胞类型
• ISSN: 1001-0602; 1748-7838
• DOI: 10.1038/cr.2014.44

Exosomes, small membrane vesicles （30-100 nm） of endocytic origin secreted by most cell types, contain functional biomolecules, which can be horizontally transferred to recipient cells [1]. Exosomes bear a specific protein and lipid composition, and carry a select set of functional mRNAs and microRNAs [2]. Recently, our group has shown that c-Met shed in exosomes can promote a proangiogenic and prometastatic phenotype in bone marrow-derived progenitor cells during melanoma progression [3]. In previous research, retrotransposon RNA transcripts, single-stranded DNA （ssDNA）,