Acute Changes in Heart Rate Variability in Subjects With Diabetes Following a Highway Traffic Exposure

Objective: To pilot a protocol to evaluate acute cardiovascular effects in in-vehicle exposure to traffic air pollutants in people with diabetes. Methods: Twenty-one volunteers with type 2 diabetes were passengers on 90- to 110-minute car rides on a busy highway. We measured in-vehicle particle numb...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2010-03, Vol.52 (3), p.324-331
Main Authors: Laumbach, Robert J., Rich, David Q., Gandhi, Sampada, Amorosa, Louis, Schneider, Stephen, Zhang, Junfeng, Ohman-Strickland, Pamela, Gong, Jicheng, Lelyanov, Oleksiy, Kipen, Howard M.
Format: Article
Language:English
Subjects:
Aged
Air
Air Pollutants - adverse effects
Air Pollutants - analysis
Air pollution
Biological and medical sciences
Blood Pressure
Carbon monoxide
Cardiac dysrhythmias
Cardiology. Vascular system
Diabetes
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Electrocardiography, Ambulatory
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Environmental Exposure - adverse effects
Environmental health
Environmental pollutants toxicology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Heart
Heart rate
Heart Rate - drug effects
Humans
Male
Medical sciences
Middle Aged
Nitrogen dioxide
ORIGINAL ARTICLES
Passengers
Toxicology
Vehicle emissions
Vehicle Emissions - analysis
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Summary:Objective: To pilot a protocol to evaluate acute cardiovascular effects in in-vehicle exposure to traffic air pollutants in people with diabetes. Methods: Twenty-one volunteers with type 2 diabetes were passengers on 90- to 110-minute car rides on a busy highway. We measured in-vehicle particle number and mass (PM2.5) nitrogen dioxide, and carbon monoxide and heart rate, heart rate variability (HRV), and blood pressure. Results: Compared with pre-ride measurements, we found a decrease in high frequency (HF) HRV from pre-ride to next day (ratio 0.66, 95% CI = 0.47 to 0.93) and an increase in low frequency to HF ratio at post-ride (ratio 1.92, 95% CI = 1.21 to 3.05) at post-ride. Interquartile range increases in measured pollutants were associated with next-day decreases in HR HRV. Conclusions: This protocol appears useful for assessing acute adverse cardiovascular effects of in-vehicle exposures among people who have diabetes.
ISSN:1076-2752
1536-5948
DOI:10.1097/JOM.0b013e3181d241fa