Abnormal myelin and axonal integrity in recently diagnosed patients with obstructive sleep apnea

• Published in: Sleep (New York, N.Y.) N.Y.), 2014-04, Vol.37 (4), p.723-732
• Main Authors: Kumar, Rajesh, Pham, Tiffany T, Macey, Paul M, Woo, Mary A, Yan-Go, Frisca L, Harper, Ronald M
• Format: Article
• Language: English
• Subjects: Abnormal Myelin and Axonal Integrity in Patients with OSA; Adult; Aged; Axons - pathology; Brain - pathology; Case-Control Studies; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; Humans; Male; Middle Aged; Myelin Sheath - pathology; Nerve Fibers, Myelinated - pathology; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - pathology
• ISSN: 0161-8105; 1550-9109
• DOI: 10.5665/sleep.3578

Patients with obstructive sleep apnea (OSA) show significant white matter injury; whether that injury represents myelin or axonal damage is unclear. The objective was to examine myelin and axonal changes in patients with newly diagnosed OSA over control subjects. Cross-sectional study. University-based medical center. Twenty-three newly-diagnosed, treatment-naïve OSA and 23 age- and sex-matched control subjects. None. Radial and axial diffusivity maps, calculated from diffusion tensor imaging data (3.0 Tesla MRI scanner), indicating diffusion perpendicular (myelin status) or parallel (axonal status) to fibers, respectively, were normalized, smoothed, and compared between groups (analysis of covariance; covariate: age). Global brain radial and axial diffusivity values, and global brain volume with myelin and axonal changes were determined, and region-of-interest analyses performed in areas of significant differences between groups based on voxel-based procedures. Global radial and axial diffusivity values were significantly reduced in OSA versus control subjects (radial, P = 0.004; axial, P = 0.019), with radial (myelin) diffusivity reduced more than axial (axonal), and more left-sided reduction for both measures. Localized declines for myelin and axonal measures appeared in the dorsal and ventral medulla, cerebellar cortex and deep nuclei, basal ganglia, hippocampus, amygdala, corpus callosum, insula, cingulate and medial frontal cortices, and other cortical areas (P < 0.005), all regions mediating functions affected in OSA. Fiber injury appears in critical medullary respiratory regulatory sites, as well as cognitive and autonomic control areas. Myelin is more affected in newly diagnosed OSA than axons, and primarily on the left side, possibly from the increased myelin sensitivity to hypoxia and asymmetric perfusion.