Dialysis Efficiency of AN69, a Semisynthetic Membrane Not Well Suited for Diffusion

AN69 membrane is not suited for diffusion, with an suggested limit at 25 mL/min dialysate flow rate. When prescribing continuous hemodialysis this threshold must be surpassed to achieve. We designed a study aimed to check if a higher dose of dialysis could be delivered efficiently with this membrane...

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Bibliographic Details
Published in:ISRN nephrology 2013, Vol.2013, p.185989-5
Main Authors: Herrera-Gutiérrez, M. E., Seller-Pérez, G., Arias Verdu, D., Jironda-Gallegos, C., Martín-Velázquez, M., Quesada-García, G.
Format: Article
Language:English
Subjects:
Clinical Study
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Summary:AN69 membrane is not suited for diffusion, with an suggested limit at 25 mL/min dialysate flow rate. When prescribing continuous hemodialysis this threshold must be surpassed to achieve. We designed a study aimed to check if a higher dose of dialysis could be delivered efficiently with this membrane. Ten ICU patients under continuous hemodiafiltration with 1.4 m2 AN69 membrane were included and once a day we set the monitor to exclusively 50 mL/min dialysate flow rate and 250 mL/min blood flow rate and after 15 minutes measured dialysate saturation for urea, creatinine, and β2-microglobulin. We detected that urea saturation of dialysate was nearly complete (1.1±0.09) for at least 40 hours, while creatinine saturation showed a large dispersion (0.86±0.22) and did not detect any relation for these variables with time, blood flow, or anticoagulation regime. Saturation of β2-microglobulin was low (0.34±0.1) and decreased discretely with time (r2=0.15, P
ISSN:2314-405X
2314-405X
DOI:10.5402/2013/185989