GATA3: a master of many trades in immune regulation

Highlights • GATA3 integrates diverse upstream signals to control gene expression. • GATA3 controls the development and function of cells of adaptive immunity. • GATA3 regulates the generation and function of innate lymphoid cells. • GATA3 function is both cell-type specific and common for multiple...

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Bibliographic Details
Published in:Trends in immunology 2014-06, Vol.35 (6), p.233-242
Main Author: Wan, Yisong Y
Format: Article
Language:English
Subjects:
Adaptive Immunity
Allergy and Immunology
Animals
Antigens
Binding sites
GATA3
GATA3 Transcription Factor - genetics
GATA3 Transcription Factor - metabolism
Gene expression
Gene Expression Regulation
Homeostasis
Humans
Immune system
Immunity - physiology
Immunity, Innate
innate lymphoid cell
Kinases
Lymphocyte Activation
Lymphocyte Subsets - immunology
Lymphocyte Subsets - metabolism
Lymphocytes
Mammals
natural killer cell
natural killer T cell
Phosphorylation
Proteins
Signal Transduction
Studies
T cell
T cell receptors
Transcription factors
Treg cell
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Summary:Highlights • GATA3 integrates diverse upstream signals to control gene expression. • GATA3 controls the development and function of cells of adaptive immunity. • GATA3 regulates the generation and function of innate lymphoid cells. • GATA3 function is both cell-type specific and common for multiple cell types.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2014.04.002