Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme

This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with 11C-methionine positron emission tomography (MET-PET) data for the treatment of glioblastoma multiforme (GBM). A total of 45 patients with GBM were treat...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Miwa, Kazuhiro, Matsuo, Masayuki, Ogawa, Shin-ichi, Shinoda, Jun, Asano, Yoshitaka, Ito, Takeshi, Yokoyama, Kazutoshi, Yamada, Jitsuhiro, Yano, Hirohito, Iwama, Toru
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Brain cancer
Care and treatment
Chemotherapy
Clinical Study
Diagnosis
Disease Progression
Disease-Free Survival
Dose Fractionation
Female
Follow-Up Studies
Glioblastoma - diagnostic imaging
Glioblastoma - radiotherapy
Glioblastoma multiforme
Health aspects
Hospitals
Humans
Magnetic Resonance Imaging
Male
Medical prognosis
Metabolism
Middle Aged
Multivariate Analysis
Necrosis
Neurosurgery
Oncology
Patients
PET imaging
Positron-Emission Tomography
Radiation therapy
Radiotherapy
Radiotherapy, Intensity-Modulated - methods
Tomography
Treatment Outcome
Tumors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with 11C-methionine positron emission tomography (MET-PET) data for the treatment of glioblastoma multiforme (GBM). A total of 45 patients with GBM were treated with Hypo-IMRT after surgery. Gross tumor volume (GTV) was defined as the area of enhanced lesion on MRI, including MET-PET avid region; clinical target volume (CTV) was the area with 5 mm margin surrounding the GTV; planning target volume (PTV) was the area with 15 mm margin surrounding the CTV, including MET-PET moderate region. Hypo-IMRT was performed in 8 fractions; planning the dose for GTV was escalated to 68 Gy and that for CTV was escalated to 56 Gy, while keeping the dose delivered to the PTV at 40 Gy. Concomitant and adjuvant TMZ chemotherapy was administered. At a median follow-up of 18.7 months, median overall survival (OS) was 20.0 months, and median progression-free survival was 13.0 months. The 1- and 2-year OS rates were 71.2% and 26.3%, respectively. Adjuvant TMZ chemotherapy was significantly predictive of OS on multivariate analysis. Late toxicity included 7 cases of Grade 3-4 radiation necrosis. Hypo-IMRT with MET-PET data appeared to result in favorable survival outcomes for patients with GBM.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/407026