Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme

This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with 11C-methionine positron emission tomography (MET-PET) data for the treatment of glioblastoma multiforme (GBM). A total of 45 patients with GBM were treat...

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Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Miwa, Kazuhiro, Matsuo, Masayuki, Ogawa, Shin-ichi, Shinoda, Jun, Asano, Yoshitaka, Ito, Takeshi, Yokoyama, Kazutoshi, Yamada, Jitsuhiro, Yano, Hirohito, Iwama, Toru
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Brain cancer
Care and treatment
Chemotherapy
Clinical Study
Diagnosis
Disease Progression
Disease-Free Survival
Dose Fractionation
Female
Follow-Up Studies
Glioblastoma - diagnostic imaging
Glioblastoma - radiotherapy
Glioblastoma multiforme
Health aspects
Hospitals
Humans
Magnetic Resonance Imaging
Male
Medical prognosis
Metabolism
Middle Aged
Multivariate Analysis
Necrosis
Neurosurgery
Oncology
Patients
PET imaging
Positron-Emission Tomography
Radiation therapy
Radiotherapy
Radiotherapy, Intensity-Modulated - methods
Tomography
Treatment Outcome
Tumors
Young Adult
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cited_by cdi_FETCH-LOGICAL-c527t-b46166c314df3cbf49917671ce3b6487453e0894c2f0d0236fb5e5736c673b293
cites cdi_FETCH-LOGICAL-c527t-b46166c314df3cbf49917671ce3b6487453e0894c2f0d0236fb5e5736c673b293
container_end_page 9
container_issue 2014
container_start_page 1
container_title BioMed research international
container_volume 2014
creator Miwa, Kazuhiro
Matsuo, Masayuki
Ogawa, Shin-ichi
Shinoda, Jun
Asano, Yoshitaka
Ito, Takeshi
Yokoyama, Kazutoshi
Yamada, Jitsuhiro
Yano, Hirohito
Iwama, Toru
description This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with 11C-methionine positron emission tomography (MET-PET) data for the treatment of glioblastoma multiforme (GBM). A total of 45 patients with GBM were treated with Hypo-IMRT after surgery. Gross tumor volume (GTV) was defined as the area of enhanced lesion on MRI, including MET-PET avid region; clinical target volume (CTV) was the area with 5 mm margin surrounding the GTV; planning target volume (PTV) was the area with 15 mm margin surrounding the CTV, including MET-PET moderate region. Hypo-IMRT was performed in 8 fractions; planning the dose for GTV was escalated to 68 Gy and that for CTV was escalated to 56 Gy, while keeping the dose delivered to the PTV at 40 Gy. Concomitant and adjuvant TMZ chemotherapy was administered. At a median follow-up of 18.7 months, median overall survival (OS) was 20.0 months, and median progression-free survival was 13.0 months. The 1- and 2-year OS rates were 71.2% and 26.3%, respectively. Adjuvant TMZ chemotherapy was significantly predictive of OS on multivariate analysis. Late toxicity included 7 cases of Grade 3-4 radiation necrosis. Hypo-IMRT with MET-PET data appeared to result in favorable survival outcomes for patients with GBM.
doi_str_mv 10.1155/2014/407026
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A total of 45 patients with GBM were treated with Hypo-IMRT after surgery. Gross tumor volume (GTV) was defined as the area of enhanced lesion on MRI, including MET-PET avid region; clinical target volume (CTV) was the area with 5 mm margin surrounding the GTV; planning target volume (PTV) was the area with 15 mm margin surrounding the CTV, including MET-PET moderate region. Hypo-IMRT was performed in 8 fractions; planning the dose for GTV was escalated to 68 Gy and that for CTV was escalated to 56 Gy, while keeping the dose delivered to the PTV at 40 Gy. Concomitant and adjuvant TMZ chemotherapy was administered. At a median follow-up of 18.7 months, median overall survival (OS) was 20.0 months, and median progression-free survival was 13.0 months. The 1- and 2-year OS rates were 71.2% and 26.3%, respectively. Adjuvant TMZ chemotherapy was significantly predictive of OS on multivariate analysis. Late toxicity included 7 cases of Grade 3-4 radiation necrosis. Hypo-IMRT with MET-PET data appeared to result in favorable survival outcomes for patients with GBM.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24977151</pmid><doi>10.1155/2014/407026</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8106-4588</orcidid><orcidid>https://orcid.org/0000-0003-2236-9282</orcidid><orcidid>https://orcid.org/0000-0002-4252-4780</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 2314-6133
ispartof BioMed research international, 2014-01, Vol.2014 (2014), p.1-9
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language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4055095
source Publicly Available Content Database (Proquest) (PQ_SDU_P3); Wiley Online Library Open Access
subjects Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Brain cancer
Care and treatment
Chemotherapy
Clinical Study
Diagnosis
Disease Progression
Disease-Free Survival
Dose Fractionation
Female
Follow-Up Studies
Glioblastoma - diagnostic imaging
Glioblastoma - radiotherapy
Glioblastoma multiforme
Health aspects
Hospitals
Humans
Magnetic Resonance Imaging
Male
Medical prognosis
Metabolism
Middle Aged
Multivariate Analysis
Necrosis
Neurosurgery
Oncology
Patients
PET imaging
Positron-Emission Tomography
Radiation therapy
Radiotherapy
Radiotherapy, Intensity-Modulated - methods
Tomography
Treatment Outcome
Tumors
Young Adult
title Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme
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