Disease Activity in Psoriatic Arthritis : Comparison of the Discriminative Capacity and Construct Validity of Six Composite Indices in a Real World

Objective. To compare, “in a real world,” the performance of the most common composite activity indices in a cohort of PsA patients. Methods. A total of 171 PsA patients were involved. The following variables were evaluated: peripheral joint assessment, patient reported of pain, physician and patien...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-12
Main Authors: Salaffi, Fausto, Ciapetti, Alessandro, Carotti, Marina, Gasparini, Stefania, Gutierrez, Marwin
Format: Article
Language:English
Subjects:
Adult
Arthritis, Psoriatic - pathology
Arthritis, Psoriatic - physiopathology
Arthritis, Psoriatic - therapy
Care and treatment
Clinical trials
Comparative analysis
Development and progression
Diagnosis
Female
Humans
Male
Middle Aged
Outcome and process assessment (Health Care)
Patients
Psoriasis
Psoriatic arthritis
Quality of life
Questionnaires
Remission (Medicine)
Remission Induction
Rheumatology
Severity of Illness Index
Skin diseases
Sociodemographics
Variables
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Summary:Objective. To compare, “in a real world,” the performance of the most common composite activity indices in a cohort of PsA patients. Methods. A total of 171 PsA patients were involved. The following variables were evaluated: peripheral joint assessment, patient reported of pain, physician and patient assessments of disease activity, patient general health status, dactylitis digit count, Leeds Enthesitis Index, Health Assessment Questionnaire (HAQ), physical and mental component summary score of the Medical Outcome Survey (SF-36), Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). To measure the disease activity, the Disease Activity Score (DAS28-ESR and DAS28-CRP), Simple Disease Activity Index (SDAI), Composite Psoriatic Disease Activity Index (CPDAI), disease activity in psoriatic arthritis (DAPSA), and Psoriatic Arthritis Disease Activity Score (PASDAS) have been calculated. The criteria for minimal disease activity (MDA) and remission were applied as external criterion. Results. The ROC were similar in all the composite measures. Only the CPDAI showed less discriminative ability. There was a high degree of correlation between all the indices (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/528105