Early Intra-Articular Complement Activation in Ankle Fractures

• Published in: BioMed research international 2014-01, Vol.2014 (2014), p.1-8
• Main Authors: Schmal, Hagen, Salzmann, Gian M., Niemeyer, Philipp, Langenmair, Elia Raoul, Guo, Renfeng, Schneider, Conny, Habel, Maria, Riedemann, Niels
• Format: Article
• Language: English
• Subjects: Adult; Ankle; Ankle Fractures - metabolism; Ankle Fractures - pathology; Ankle Fractures - therapy; Ankle Joint - metabolism; Ankle Joint - pathology; Body mass index; Clinical Study; Complement Activation; Complement System Proteins - metabolism; Cytokines; Fibroblast Growth Factor 2 - metabolism; Fibroblast growth factors; Gene Expression Regulation; Humans; Injuries; Insulin-Like Growth Factor I - metabolism; Interleukin-1beta - metabolism; Male; Methods; Middle Aged; Open access publishing; Osteochondritis Dissecans - metabolism; Osteochondritis Dissecans - pathology; Osteochondritis Dissecans - therapy; Proteins; Rheumatic diseases; Surgery; Time Factors; Trauma
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2014/426893

Cytokine regulation possibly influences long term outcome following ankle fractures, but little is known about synovial fracture biochemistry. Eight patients with an ankle dislocation fracture were included in a prospective case series and matched with patients suffering from grade 2 osteochondritis dissecans (OCD) of the ankle. All fractures needed external fixation during which joint effusions were collected. Fluid analysis was done by ELISA measuring aggrecan, bFGF, IL-1β, IGF-1, and the complement components C3a, C5a, and C5b-9. The time periods between occurrence of fracture and collection of effusion were only significantly associated with synovial aggrecan and C5b-9 levels (P