Antiphospholipid Antibodies in Women Undergoing In Vitro Fertilization Treatment : Clinical Value of IgA Anti-β2glycoprotein I Antibodies Determination

Implantation failure could be related to antiphospholipid antibodies (aPL). We retrospectively analyzed the usefulness of aPL determination in women undergoing IVF. Conventional aPL of the antiphospholipid syndrome, lupus anticoagulant (LA), anticardiolipin antibodies (aCL), anti-β2glycoprotein I (a...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-5
Main Authors: Paulmyer-Lacroix, Odile, Despierres, Laura, Courbiere, Blandine, Bardin, Nathalie
Format: Article
Language:English
Subjects:
Adult
Antibodies, Antiphospholipid - blood
beta 2-Glycoprotein I
Embryo Implantation
Female
Fertilization in Vitro
Humans
Immunoglobulin A - blood
Male
Pregnancy - blood
Prospective Studies
Retrospective Studies
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Summary:Implantation failure could be related to antiphospholipid antibodies (aPL). We retrospectively analyzed the usefulness of aPL determination in women undergoing IVF. Conventional aPL of the antiphospholipid syndrome, lupus anticoagulant (LA), anticardiolipin antibodies (aCL), anti-β2glycoprotein I (aβ2GPI) antibodies, and IgG and IgM isotypes as well as IgA isotype were analyzed in women presenting with at least two implantation failures after in vitro fertilization (IVF). In a population of 40 IVF patients, a total prevalence of 20% (8/40) of aPL was found, significantly different from that of the control population (100 healthy blood donors, P
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/314704