NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

Engineered nanomaterials (ENMs) continue to attract significant attention because they have novel physicochemical properties that can improve the functions of products that will benefit human lives. However, the physicochemical properties that make ENMs attractive could interact with biological syst...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2013-05, Vol.9 (9-10), p.1595-1607
Main Authors: Sun, Bingbing, Wang, Xiang, Ji, Zhaoxia, Li, Ruibin, Xia, Tian
Format: Article
Language:English
Subjects:
Activation
Activation analysis
Biological
Carrier Proteins - metabolism
Cathepsin B - metabolism
Design engineering
engineered nanomaterials
Food science
Humans
Immune systems
inflammasomes
Inflammasomes - metabolism
inflammation
Ion Transport
Lysosomes - metabolism
Nanomaterials
Nanostructures
Nanotechnology
nanotoxicology
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3
Potassium - metabolism
Reactive Oxygen Species - metabolism
Strategy
Therapy
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Summary:Engineered nanomaterials (ENMs) continue to attract significant attention because they have novel physicochemical properties that can improve the functions of products that will benefit human lives. However, the physicochemical properties that make ENMs attractive could interact with biological systems and induce cascades of events that cause toxicological effects. Recently, there have been more studies suggesting inflammasome activation may play an important role in ENM‐induced biological responses. Inflammasomes are a family of multiprotein complexes that are increasingly recognized as major mediators of the host immune system. Among these, NLRP3 inflammasome is the most studied that could directly interact with ENMs to generate inflammatory responses. In this review, the ENM physicochemical properties are linked to NLRP3 inflammasome activation. An understanding of the mechanisms of ENM–NLRP3 inflammasome interactions will provide us with strategies for safer nanomaterial design and therapy. Mechanisms of NLRP3 inflammasome activation induced by engineered nanomaterials (ENMs): the physicochemical properties of ENMs that can be linked to NLRP3 inflammasome activation are reviewed. The elucidation of mechanisms of ENM–NLRP3 inflammasome interaction will help to develop safer ENMs and a potential therapy for ENM‐induced adverse health effects.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201201962