Effects of Dietary Supplementation with Agaricus sylvaticus Schaeffer on Glycemia and Cholesterol after Streptozotocin-Induced Diabetes in Rats

• Published in: Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-10
• Main Authors: Wadt, Nilsa S. Y., Lara, Marx A. N., Esquerdo, Kamilla F., França, Cristiane M., Mascaro, Marcelo Betti, Bach, Erna E.
• Format: Article
• Language: English
• Subjects: Agaricus; Agaricus sylvaticus; Alkaline phosphatase; Biochemical tests; Blood glucose; Cholesterol; Chromatography; Complications and side effects; Damage prevention; Diabetes; Diabetes mellitus (insulin dependent); Dietary minerals; Dietary supplements; Enzymes; Food consumption; Gastroenterology; Glucose; Health aspects; High density lipoprotein; Hyperglycemia; Hyperplasia; Insulin; Iron; Islets of Langerhans; Metabolism; Microscopic analysis; Mortality; Mushrooms; Nutrition; Pancreas; Pharmacology, Experimental; Rats; Streptozocin; Sugar; Systematic review; Transaminase; Transferrins; Triglycerides; Urea; Water consumption
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2014/107629

This study evaluated the effect of the Agaricus sylvaticus (sun mushroom) on biochemical tests of the plasma and on the morphology of the pancreas in an experimental model of type I diabetes mellitus (DM1) induced by streptozotocin. One gram of dry A. sylvaticus was homogenized and mixed with the chow. Male Wistar rats were allocated as follows: normoglycemic control that received commercial chow; normoglycemic control group that received chow with A. sylvaticus; diabetic group that received commercial chow; and diabetic group that received chow with A. sylvaticus. Weight, food, and water consumption were measured every two days. Blood glucose levels were measured twice a week. After 30 days, the animals were euthanized and blood was collected for the analysis of cholesterol, HDL, triglycerides, blood sugar, glutamic-pyruvic transaminase (GPT), alkaline phosphatase, iron, transferrin, and urea. The pancreas was processed for microscopic analysis. A. sylvaticus modulated the levels of cholesterol, HDL, triglycerides, blood sugar, GPT, alkaline phosphatase, iron, transferrin, and urea to levels similar to those found in the controls and led to compensatory hyperplasia of the islets of Langerhans. A. sylvaticus is potentially beneficial in the control of type 1 diabetes, and it may also prevent pancreas damage.