CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features

Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk f...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Chiou, Hui-Ling, Chou, Ying-Erh, Chen, Tzy-Yen, Yang, Shun-Fa, Lee, Hsiang-Lin, Hsieh, Ming-Ju
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Biomarkers, Tumor - genetics
Biomedical research
Cancer therapies
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Case-Control Studies
Cell adhesion & migration
Chemotherapy
Disease Susceptibility
Female
Genes
Genetic Predisposition to Disease
Genotype
Hepatitis
Hepatoma
Hospitals
Humans
Hyaluronan Receptors - genetics
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Male
Medical prognosis
Medical research
Metastasis
Middle Aged
Mortality
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
Risk Factors
Rodents
Single nucleotide polymorphisms
Smoking
Stress response
Studies
Taiwan
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Summary:Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to HCC susceptibility and clinicopathological characteristics. Six SNPs of CD44 were analyzed using a real-time polymerase chain reaction (PCR) in 203 patients with HCC and in 561 cancer-free controls. We determined that the individuals carrying at least one G allele at CD44 rs187115 has higher risk of developing HCC than did wild-type (AA) carriers. We further observed that the CD44 rs187115 polymorphisms with at least one G allele had a higher frequency of distribution in nonsmoking stage III/IV HCC patients, compared with wild-type carriers. Our results suggested that patients with CD44 rs187115 variant genotypes (AG+GG) were associated with a higher risk of HCC development and that these patients might possess chemoresistance, causing more likely progression to late-stage HCC than wild-type carriers without the overexpression of CD44 induced by heavy smoking. CD44 rs187115 might be involved in CD44 isoform expression of p53 stress response in HCC and provide a marker for predicting worst-case prognosis of HCC.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/231474