CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features

Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk f...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Chiou, Hui-Ling, Chou, Ying-Erh, Chen, Tzy-Yen, Yang, Shun-Fa, Lee, Hsiang-Lin, Hsieh, Ming-Ju
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Biomarkers, Tumor - genetics
Biomedical research
Cancer therapies
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Case-Control Studies
Cell adhesion & migration
Chemotherapy
Disease Susceptibility
Female
Genes
Genetic Predisposition to Disease
Genotype
Hepatitis
Hepatoma
Hospitals
Humans
Hyaluronan Receptors - genetics
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Male
Medical prognosis
Medical research
Metastasis
Middle Aged
Mortality
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
Risk Factors
Rodents
Single nucleotide polymorphisms
Smoking
Stress response
Studies
Taiwan
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c527t-d430cfe93dd3bd5640d842f8f2bffbcd4f116d7eaa8272b44e96f8a5cb354a5b3
cites cdi_FETCH-LOGICAL-c527t-d430cfe93dd3bd5640d842f8f2bffbcd4f116d7eaa8272b44e96f8a5cb354a5b3
container_end_page 9
container_issue 2014
container_start_page 1
container_title BioMed research international
container_volume 2014
creator Chiou, Hui-Ling
Chou, Ying-Erh
Chen, Tzy-Yen
Yang, Shun-Fa
Lee, Hsiang-Lin
Hsieh, Ming-Ju
description Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to HCC susceptibility and clinicopathological characteristics. Six SNPs of CD44 were analyzed using a real-time polymerase chain reaction (PCR) in 203 patients with HCC and in 561 cancer-free controls. We determined that the individuals carrying at least one G allele at CD44 rs187115 has higher risk of developing HCC than did wild-type (AA) carriers. We further observed that the CD44 rs187115 polymorphisms with at least one G allele had a higher frequency of distribution in nonsmoking stage III/IV HCC patients, compared with wild-type carriers. Our results suggested that patients with CD44 rs187115 variant genotypes (AG+GG) were associated with a higher risk of HCC development and that these patients might possess chemoresistance, causing more likely progression to late-stage HCC than wild-type carriers without the overexpression of CD44 induced by heavy smoking. CD44 rs187115 might be involved in CD44 isoform expression of p53 stress response in HCC and provide a marker for predicting worst-case prognosis of HCC.
doi_str_mv 10.1155/2014/231474
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4058263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A427022219</galeid><sourcerecordid>A427022219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-d430cfe93dd3bd5640d842f8f2bffbcd4f116d7eaa8272b44e96f8a5cb354a5b3</originalsourceid><addsrcrecordid>eNqN0t1r1TAYB-AiihtzV14rBW9kcly-294MRuc2YaCgXoe3-TgnI01q0irnv7el8_hxo7lJIE9-5E3eoniO0VuMOT8nCLNzQjGr2KPieFlsBGb48WFN6VFxmvM9mkeNBWrE0-KIsKbClKDjAtorxsobE0z5Mfp9H9Owc7nPZQzlrRlgjMp4P3lIZQtJuRB7KD9NWZlhdJ3zbtyXEHTZehecivOBXfRx61R5bWCcksnPiicWfDanD_NJ8eX63ef2dnP34eZ9e3m3UZxU40YzipQ1DdWadpoLhnTNiK0t6aztlGYWY6ErA1CTinSMmUbYGrjqKGfAO3pSXKy5w9T1RisTxgReDsn1kPYygpN_7gS3k9v4TTLEayLoHPD6ISDFr5PJo-xdXqqHYOKUJeZC1LxhXPwHZZhWtOFkpq_-ovdxSmF-iUVVDcGobn6pLXgjXbBxvqJaQuUlIxUihOBFvVmVSjHnZOyhOozk0g5yaQe5tsOsX_7-IAf78_NncLaCnQsavrt_pL1YsZmJsXDAjPOqQfQHdeXF7w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547921089</pqid></control><display><type>article</type><title>CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features</title><source>Wiley Online Library Open Access</source><source>Publicly Available Content (ProQuest)</source><creator>Chiou, Hui-Ling ; Chou, Ying-Erh ; Chen, Tzy-Yen ; Yang, Shun-Fa ; Lee, Hsiang-Lin ; Hsieh, Ming-Ju</creator><contributor>Weng, Chia-Jui</contributor><creatorcontrib>Chiou, Hui-Ling ; Chou, Ying-Erh ; Chen, Tzy-Yen ; Yang, Shun-Fa ; Lee, Hsiang-Lin ; Hsieh, Ming-Ju ; Weng, Chia-Jui</creatorcontrib><description>Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to HCC susceptibility and clinicopathological characteristics. Six SNPs of CD44 were analyzed using a real-time polymerase chain reaction (PCR) in 203 patients with HCC and in 561 cancer-free controls. We determined that the individuals carrying at least one G allele at CD44 rs187115 has higher risk of developing HCC than did wild-type (AA) carriers. We further observed that the CD44 rs187115 polymorphisms with at least one G allele had a higher frequency of distribution in nonsmoking stage III/IV HCC patients, compared with wild-type carriers. Our results suggested that patients with CD44 rs187115 variant genotypes (AG+GG) were associated with a higher risk of HCC development and that these patients might possess chemoresistance, causing more likely progression to late-stage HCC than wild-type carriers without the overexpression of CD44 induced by heavy smoking. CD44 rs187115 might be involved in CD44 isoform expression of p53 stress response in HCC and provide a marker for predicting worst-case prognosis of HCC.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/231474</identifier><identifier>PMID: 24971320</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adult ; Aged ; Alleles ; Biomarkers, Tumor - genetics ; Biomedical research ; Cancer therapies ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - pathology ; Case-Control Studies ; Cell adhesion &amp; migration ; Chemotherapy ; Disease Susceptibility ; Female ; Genes ; Genetic Predisposition to Disease ; Genotype ; Hepatitis ; Hepatoma ; Hospitals ; Humans ; Hyaluronan Receptors - genetics ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - pathology ; Male ; Medical prognosis ; Medical research ; Metastasis ; Middle Aged ; Mortality ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Real-Time Polymerase Chain Reaction ; Risk Factors ; Rodents ; Single nucleotide polymorphisms ; Smoking ; Stress response ; Studies ; Taiwan</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-9</ispartof><rights>Copyright © 2014 Ying-Erh Chou et al.</rights><rights>COPYRIGHT 2014 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2014 Ying-Erh Chou et al. Ying-Erh Chou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Ying-Erh Chou et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-d430cfe93dd3bd5640d842f8f2bffbcd4f116d7eaa8272b44e96f8a5cb354a5b3</citedby><cites>FETCH-LOGICAL-c527t-d430cfe93dd3bd5640d842f8f2bffbcd4f116d7eaa8272b44e96f8a5cb354a5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1547921089/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1547921089?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25752,27923,27924,37011,37012,44589,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24971320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Weng, Chia-Jui</contributor><creatorcontrib>Chiou, Hui-Ling</creatorcontrib><creatorcontrib>Chou, Ying-Erh</creatorcontrib><creatorcontrib>Chen, Tzy-Yen</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Lee, Hsiang-Lin</creatorcontrib><creatorcontrib>Hsieh, Ming-Ju</creatorcontrib><title>CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to HCC susceptibility and clinicopathological characteristics. Six SNPs of CD44 were analyzed using a real-time polymerase chain reaction (PCR) in 203 patients with HCC and in 561 cancer-free controls. We determined that the individuals carrying at least one G allele at CD44 rs187115 has higher risk of developing HCC than did wild-type (AA) carriers. We further observed that the CD44 rs187115 polymorphisms with at least one G allele had a higher frequency of distribution in nonsmoking stage III/IV HCC patients, compared with wild-type carriers. Our results suggested that patients with CD44 rs187115 variant genotypes (AG+GG) were associated with a higher risk of HCC development and that these patients might possess chemoresistance, causing more likely progression to late-stage HCC than wild-type carriers without the overexpression of CD44 induced by heavy smoking. CD44 rs187115 might be involved in CD44 isoform expression of p53 stress response in HCC and provide a marker for predicting worst-case prognosis of HCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical research</subject><subject>Cancer therapies</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Case-Control Studies</subject><subject>Cell adhesion &amp; migration</subject><subject>Chemotherapy</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hepatitis</subject><subject>Hepatoma</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyaluronan Receptors - genetics</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Single nucleotide polymorphisms</subject><subject>Smoking</subject><subject>Stress response</subject><subject>Studies</subject><subject>Taiwan</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqN0t1r1TAYB-AiihtzV14rBW9kcly-294MRuc2YaCgXoe3-TgnI01q0irnv7el8_hxo7lJIE9-5E3eoniO0VuMOT8nCLNzQjGr2KPieFlsBGb48WFN6VFxmvM9mkeNBWrE0-KIsKbClKDjAtorxsobE0z5Mfp9H9Owc7nPZQzlrRlgjMp4P3lIZQtJuRB7KD9NWZlhdJ3zbtyXEHTZehecivOBXfRx61R5bWCcksnPiicWfDanD_NJ8eX63ef2dnP34eZ9e3m3UZxU40YzipQ1DdWadpoLhnTNiK0t6aztlGYWY6ErA1CTinSMmUbYGrjqKGfAO3pSXKy5w9T1RisTxgReDsn1kPYygpN_7gS3k9v4TTLEayLoHPD6ISDFr5PJo-xdXqqHYOKUJeZC1LxhXPwHZZhWtOFkpq_-ovdxSmF-iUVVDcGobn6pLXgjXbBxvqJaQuUlIxUihOBFvVmVSjHnZOyhOozk0g5yaQe5tsOsX_7-IAf78_NncLaCnQsavrt_pL1YsZmJsXDAjPOqQfQHdeXF7w</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Chiou, Hui-Ling</creator><creator>Chou, Ying-Erh</creator><creator>Chen, Tzy-Yen</creator><creator>Yang, Shun-Fa</creator><creator>Lee, Hsiang-Lin</creator><creator>Hsieh, Ming-Ju</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features</title><author>Chiou, Hui-Ling ; Chou, Ying-Erh ; Chen, Tzy-Yen ; Yang, Shun-Fa ; Lee, Hsiang-Lin ; Hsieh, Ming-Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-d430cfe93dd3bd5640d842f8f2bffbcd4f116d7eaa8272b44e96f8a5cb354a5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomedical research</topic><topic>Cancer therapies</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Case-Control Studies</topic><topic>Cell adhesion &amp; migration</topic><topic>Chemotherapy</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hepatitis</topic><topic>Hepatoma</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyaluronan Receptors - genetics</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Risk Factors</topic><topic>Rodents</topic><topic>Single nucleotide polymorphisms</topic><topic>Smoking</topic><topic>Stress response</topic><topic>Studies</topic><topic>Taiwan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiou, Hui-Ling</creatorcontrib><creatorcontrib>Chou, Ying-Erh</creatorcontrib><creatorcontrib>Chen, Tzy-Yen</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Lee, Hsiang-Lin</creatorcontrib><creatorcontrib>Hsieh, Ming-Ju</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiou, Hui-Ling</au><au>Chou, Ying-Erh</au><au>Chen, Tzy-Yen</au><au>Yang, Shun-Fa</au><au>Lee, Hsiang-Lin</au><au>Hsieh, Ming-Ju</au><au>Weng, Chia-Jui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to HCC susceptibility and clinicopathological characteristics. Six SNPs of CD44 were analyzed using a real-time polymerase chain reaction (PCR) in 203 patients with HCC and in 561 cancer-free controls. We determined that the individuals carrying at least one G allele at CD44 rs187115 has higher risk of developing HCC than did wild-type (AA) carriers. We further observed that the CD44 rs187115 polymorphisms with at least one G allele had a higher frequency of distribution in nonsmoking stage III/IV HCC patients, compared with wild-type carriers. Our results suggested that patients with CD44 rs187115 variant genotypes (AG+GG) were associated with a higher risk of HCC development and that these patients might possess chemoresistance, causing more likely progression to late-stage HCC than wild-type carriers without the overexpression of CD44 induced by heavy smoking. CD44 rs187115 might be involved in CD44 isoform expression of p53 stress response in HCC and provide a marker for predicting worst-case prognosis of HCC.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24971320</pmid><doi>10.1155/2014/231474</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2314-6133
ispartof BioMed research international, 2014-01, Vol.2014 (2014), p.1-9
issn 2314-6133
2314-6141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4058263
source Wiley Online Library Open Access; Publicly Available Content (ProQuest)
subjects Adult
Aged
Alleles
Biomarkers, Tumor - genetics
Biomedical research
Cancer therapies
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Case-Control Studies
Cell adhesion & migration
Chemotherapy
Disease Susceptibility
Female
Genes
Genetic Predisposition to Disease
Genotype
Hepatitis
Hepatoma
Hospitals
Humans
Hyaluronan Receptors - genetics
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Male
Medical prognosis
Medical research
Metastasis
Middle Aged
Mortality
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
Risk Factors
Rodents
Single nucleotide polymorphisms
Smoking
Stress response
Studies
Taiwan
title CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T00%3A44%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CD44%20Gene%20Polymorphisms%20on%20Hepatocellular%20Carcinoma%20Susceptibility%20and%20Clinicopathologic%20Features&rft.jtitle=BioMed%20research%20international&rft.au=Chiou,%20Hui-Ling&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/231474&rft_dat=%3Cgale_pubme%3EA427022219%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c527t-d430cfe93dd3bd5640d842f8f2bffbcd4f116d7eaa8272b44e96f8a5cb354a5b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1547921089&rft_id=info:pmid/24971320&rft_galeid=A427022219&rfr_iscdi=true