White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats

This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400 mg/kg) or intravenous injection (40 mg/kg) of puerarin, pretreated with or without...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-8
Main Authors: Su, Zi-Ren, Fu, Lu-Di, Zhan, Janis Ya-Xian, Li, Yu-Cui, Zheng, Yi-Feng, Chen, Xiao-Ying, Hou, Shao-Zhen, Su, Zu-Qing, Chen, Hai-Ming, Liang, Yong-Zhuo, Lin, Ji
Format: Article
Language:English
Subjects:
Bioavailability
Cytochrome
Drug dosages
Gene expression
Glycoproteins
Intravenous administration
Laboratory animals
Metabolism
Oral administration
Pharmacokinetics
Piper nigrum
Piperine
Rats
Rodents
Tuberculosis
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Summary:This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400 mg/kg) or intravenous injection (40 mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20 mg/kg) increased the Cmax of puerarin by 1.30-fold or 1.64-fold and the AUC0–∞ by 133% or 157%, respectively. In contrast, coadministration of white pepper (125 or 250 mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively. On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper. The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes. Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions.
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/796890