Numerical Simulation and Clinical Implications of Stenosis in Coronary Blood Flow

Fractional flow reserve (FFR) is the gold standard to guide coronary interventions. However it can only be obtained via invasive angiography. The objective of this study is to propose a noninvasive method to determine FFRCT by combining computed tomography angiographic (CTA) images and computational...

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Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-10
Main Authors: Luo, Tong, Zhong, Liang, Zhang, Jun-Mei, Huo, Yunlong, Tan, Swee Yaw, Wong, Aaron Sung Lung, Su, Boyang, Wan, Min, Zhao, Xiaodan, Kassab, Ghassan S., Lee, Heow Pueh, Khoo, Boo Cheong, Kang, Chang-Wei, Ba, Te, Tan, Ru San
Format: Article
Language:English
Subjects:
Anatomy & physiology
Angiography
Animals
Biomedical research
Blood
Blood Flow Velocity
Boundary conditions
Cardiovascular disease
Care and treatment
Compliance
Coronary Circulation
Coronary heart disease
Coronary Stenosis - pathology
Coronary Stenosis - physiopathology
Coronary vessels
Coronary Vessels - pathology
Coronary Vessels - physiopathology
Fluid dynamics
Heart
Heart attacks
Humans
Medical research
Medicine, Experimental
Models, Cardiovascular
Myocardium
NMR
Nuclear magnetic resonance
Reynolds number
Simulation
Stenosis
Studies
Swine
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cited_by cdi_FETCH-LOGICAL-c527t-4daed6fdff65b611f22857380197d8ad4ce1d250489b609aea80896f0e7314e3
cites cdi_FETCH-LOGICAL-c527t-4daed6fdff65b611f22857380197d8ad4ce1d250489b609aea80896f0e7314e3
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container_issue 2014
container_start_page 1
container_title BioMed research international
container_volume 2014
creator Luo, Tong
Zhong, Liang
Zhang, Jun-Mei
Huo, Yunlong
Tan, Swee Yaw
Wong, Aaron Sung Lung
Su, Boyang
Wan, Min
Zhao, Xiaodan
Kassab, Ghassan S.
Lee, Heow Pueh
Khoo, Boo Cheong
Kang, Chang-Wei
Ba, Te
Tan, Ru San
description Fractional flow reserve (FFR) is the gold standard to guide coronary interventions. However it can only be obtained via invasive angiography. The objective of this study is to propose a noninvasive method to determine FFRCT by combining computed tomography angiographic (CTA) images and computational fluid dynamics (CFD) technique. Utilizing the method, this study explored the effects of diameter stenosis (DS), stenosis length, and location on FFRCT. The baseline left anterior descending (LAD) model was reconstructed from CTA of a healthy porcine heart. A series of models were created by adding an idealized stenosis (with DS from 45% to 75%, stenosis length from 4 mm to 16 mm, and at 4 locations separately). Through numerical simulations, it was found that FFRCT decreased (from 0.89 to 0.74), when DS increased (from 45% to 75%). Similarly, FFRCT decreased with the increase of stenosis length and the stenosis located at proximal position had lower FFRCT than that at distal position. These findings are consistent with clinical observations. Applying the same method on two patients’ CTA images yielded FFRCT close to the FFR values obtained via invasive angiography. The proposed noninvasive computation of FFRCT is promising for clinical diagnosis of CAD.
doi_str_mv 10.1155/2014/514729
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source Wiley-Blackwell Open Access Collection; Publicly Available Content Database
subjects Anatomy & physiology
Angiography
Animals
Biomedical research
Blood
Blood Flow Velocity
Boundary conditions
Cardiovascular disease
Care and treatment
Compliance
Coronary Circulation
Coronary heart disease
Coronary Stenosis - pathology
Coronary Stenosis - physiopathology
Coronary vessels
Coronary Vessels - pathology
Coronary Vessels - physiopathology
Fluid dynamics
Heart
Heart attacks
Humans
Medical research
Medicine, Experimental
Models, Cardiovascular
Myocardium
NMR
Nuclear magnetic resonance
Reynolds number
Simulation
Stenosis
Studies
Swine
title Numerical Simulation and Clinical Implications of Stenosis in Coronary Blood Flow
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