Plasmid-mediated AmpC β-lactamase (CMY-2) gene in Salmonella typhimurium isolated from diarrheic pigs in South Korea

Salmonella resistant to third-generation cephalosporin has been isolated from an increasing number of animals worldwide. The purpose of this study was to examine ESBL (extended-spectrum β-lactamases)-producing and PABL (plasmid-mediated AmpC β-lactamases)-producing Salmonella isolates from pigs in S...

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Bibliographic Details
Published in:BMC research notes 2014-06, Vol.7 (1), p.329-329, Article 329
Main Authors: Lee, Ki-Eun, Lim, Seong-In, Choi, Hwan-Won, Lim, Suk-Kyung, Song, Jae-Young, An, Dong-Jun
Format: Article
Language:English
Subjects:
Animals
beta-Lactamases - genetics
Diarrhea - microbiology
Diarrhea - veterinary
Plasmids
Republic of Korea
Salmonella typhimurium - isolation & purification
Swine
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Summary:Salmonella resistant to third-generation cephalosporin has been isolated from an increasing number of animals worldwide. The purpose of this study was to examine ESBL (extended-spectrum β-lactamases)-producing and PABL (plasmid-mediated AmpC β-lactamases)-producing Salmonella isolates from pigs in South Korea. Salmonella Typhimurium KVCC-BA1300259 was resistant to ampicillin, amoxicillin/clavulanic acid, cephalothin, chloramphenicol, florfenicol, cefoxithin, gentamicin, nalidixic acid, trimethoprim/sulfamethoxazole, tetracycline, and ceftiofur. The results of a double-disk synergy test and PCR confirmed that the isolate produced CMY-2 (PABL). Analysis of plasmid incompatibility (Inc) groups revealed the presence of IncA/C and IncFIB, indicating antimicrobial resistance. This study is the first to identify S. Typhimurium isolates harboring CMY-2 in pigs in South Korea. The presence of CMY-2 in pigs poses a significant threat of possible horizontal spread between animals and humans.
ISSN:1756-0500
1756-0500
DOI:10.1186/1756-0500-7-329