An Investigation into the Parameters Affecting Preparation of Polybutyl Cyanoacrylate Nanoparticles by Emulsion Polymerization

Emulsion polymerization was used to synthesize poly butyl cyanoacrylate nanoparticles in presence of steric stabilizer dextran 70. Nanoparticles were characterized by particle size analysis, scanning electron microscopy and light microscopy. Polymerization factors affecting particle size and distrib...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2014-07, Vol.29 (3), p.357-361
Main Authors: Shahmabadi, Hasan Ebrahimi, Doun, Seyed Kazem Bagherpour, Alavi, Seyed Ebrahim, Mortazavi, Mehri, Saffari, Zahra, Farahnak, Maryam, Akbarzadeh, Azim
Format: Article
Language:English
Subjects:
Analysis
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Dextran
Drug delivery systems
Emulsion polymerization
Investigations
Life Sciences
Microbiology
Nanoparticles
Nitriles
Original
Original Article
Pathology
Pharmacology
Polymerization
Surface active agents
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Summary:Emulsion polymerization was used to synthesize poly butyl cyanoacrylate nanoparticles in presence of steric stabilizer dextran 70. Nanoparticles were characterized by particle size analysis, scanning electron microscopy and light microscopy. Polymerization factors affecting particle size and distribution such as dextran 70, polysorbate 80 (PS 80) and H + concentration, polymerization time and temperature, and sonication were studied. Distinct concentrations of stabilizer were needed to produce proper nanoparticles. In this case, the appropriate value was 2 % of total volume. At pH 4 significant decrease in production efficiency demonstrated the substantial effect of H + concentration on nanoparticles. Furthermore significant increases in particle size and distribution was observed at 50 °C compared to room temperature. 0.001 % (v/v) PS 80 represented notable influence on size and distribution. In addition, shaped nanoparticles were obtained by altering polymerization time from 5.5 h to 18 h. Finally, nanoparticle features were influenced by different factors. Appropriate manipulating of such factors can lead to obtaining desirable nanoparticles.
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-013-0325-0