A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats

The increase in incidence and prevalence of neurodegenerative diseases highlights the need for a more comprehensive understanding of how food components may affect neural systems. In particular, flavonoids have been recognized as promising agents capable of influencing different aspects of synaptic...

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Bibliographic Details
Published in:Neuropharmacology 2014-04, Vol.79 (100), p.335-344
Main Authors: Rendeiro, Catarina, Foley, Andrew, Lau, Vera C., Ring, Rebecca, Rodriguez-Mateos, Ana, Vauzour, David, Williams, Claire M., Regan, Ciaran, Spencer, Jeremy P.E.
Format: Article
Language:English
Subjects:
Animals
BDNF
Brain-Derived Neurotrophic Factor - metabolism
Cyclic AMP Response Element-Binding Protein - metabolism
Cytoskeletal Proteins - metabolism
Dentate Gyrus - metabolism
Flavonoid
Flavonoids - therapeutic use
Hippocampus
Hippocampus - metabolism
Learning
Male
MAP Kinase Signaling System - physiology
Maze Learning - physiology
Memory
Memory Disorders - diet therapy
Memory Disorders - metabolism
Memory, Short-Term - physiology
Nerve Tissue Proteins - metabolism
Neural Cell Adhesion Molecule L1 - metabolism
NMDR2B
Proto-Oncogene Proteins c-akt - metabolism
PSA-NCAM
Rats
Rats, Wistar
Receptors, AMPA - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Sialic Acids - metabolism
Space Perception - physiology
TOR Serine-Threonine Kinases - metabolism
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Summary:The increase in incidence and prevalence of neurodegenerative diseases highlights the need for a more comprehensive understanding of how food components may affect neural systems. In particular, flavonoids have been recognized as promising agents capable of influencing different aspects of synaptic plasticity resulting in improvements in memory and learning in both animals and humans. Our previous studies highlight the efficacy of flavonoids in reversing memory impairments in aged rats, yet little is known about the effects of these compounds in healthy animals, particularly with respect to the molecular mechanisms by which flavonoids might alter the underlying synaptic modifications responsible for behavioral changes. We demonstrate that a 3-week intervention with two dietary doses of flavonoids (Dose I: 8.7 mg/day and Dose II: 17.4 mg/day) facilitates spatial memory acquisition and consolidation (24 recall) (p 
ISSN:0028-3908
1873-7064
DOI:10.1016/j.neuropharm.2013.12.003