Risk factors for methicillin-resistant Staphylococcus aureus bacteraemia differ depending on the control group chosen

Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia cause significant morbidity and mortality in hospitalized patients. Using a nested case-control design, 204 MRSA bacteraemia cases were compared to 301 unmatched methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia controls a...

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Bibliographic Details
Published in:Epidemiology and infection 2013-11, Vol.141 (11), p.2376-2383
Main Authors: POGORZELSKA-MAZIARZ, M., FURUYA, E. Y., LARSON, E. L.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Bacteremia - microbiology
Bacterial diseases
Bacterial sepsis
Bacteriology
Biological and medical sciences
Case-Control Studies
Data Interpretation, Statistical
Disease
Female
Fundamental and applied biological sciences. Psychology
Hospital costs
Hospitalization
Human bacterial diseases
Humans
Infectious diseases
Length of stay
Male
Medical sciences
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Microbiology
Miscellaneous
Morbidity
Mortality
MRSA
Odds Ratio
Original Papers
Ostomy
Research Design
Risk Factors
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus infections
Virulence Factors
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Summary:Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia cause significant morbidity and mortality in hospitalized patients. Using a nested case-control design, 204 MRSA bacteraemia cases were compared to 301 unmatched methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia controls and were matched 1:2 with non-infected controls. The independent risk factors for MRSA bacteraemia compared to MSSA bacteraemia were older age (P = 0·048), major organ transplant during current hospital stay (P = 0·016) and quinolone use (P = 0·016). Cases were more likely than non-infected controls to have renal failure (P = 0·003), cirrhosis (P = 0·013), and a central venous catheter (P = 0·003) after controlling for other risk factors. This large case-control study made it possible to assess risk factors for MRSA bacteraemia using two sets of controls and showed that risk factors differed greatly depending on the control group chosen. These results confirm the need for careful selection of appropriate control groups and the need to carefully adjust for underlying severity of illness.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268813000174