Avian hepatitis B viruses： Molecular and cellular biology, phylogenesis, and host tropism

The human hepatitis B virus （HBV） and the duck hepatitis B virus （DHBV） share several fundamental features. Both viruses have a partially double-stranded DNA genome that is replicated via a RNA intermediate and the coding open reading frames （ORFs） overlap extensively. In addition, the genomic and s...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2007-01, Vol.13 (1), p.91-103
Main Authors: Funk, Anneke, Mhamdi, Mouna, Will, Hans, Sirma, Hüseyin
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Avihepadnavirus - genetics
Avihepadnavirus - growth & development
Avihepadnavirus - pathogenicity
Avihepadnavirus - physiology
Disease Models, Animal
DNA, Viral - genetics
Ducks
Hepadnaviridae Infections - drug therapy
Hepadnaviridae Infections - pathology
Hepadnaviridae Infections - physiopathology
Hepatitis B Virus, Duck - genetics
Hepatitis B Virus, Duck - growth & development
Hepatitis B Virus, Duck - pathogenicity
Hepatitis B Virus, Duck - physiology
Molecular Sequence Data
Morphogenesis - physiology
Topic Highlight
Tropism - physiology
Viral Proteins - analysis
Viral Proteins - physiology
Viral Vaccines - genetics
Viral Vaccines - therapeutic use
Virus Internalization
Virus Replication - physiology
乙型病毒肝炎
树状细胞
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Description
Summary:The human hepatitis B virus （HBV） and the duck hepatitis B virus （DHBV） share several fundamental features. Both viruses have a partially double-stranded DNA genome that is replicated via a RNA intermediate and the coding open reading frames （ORFs） overlap extensively. In addition, the genomic and structural organization, as well as replication and biological characteristics, are very similar in both viruses. Host of the key features of hepadnaviral infection were first discovered in the DHBV model system and subsequently confirmed for HBV. There are, however, several differences between human HBV and DHBV. This review will focus on the molecular and cellular biology, evolution, and host adaptation of the avian hepatitis B viruses with particular emphasis on DHBV as a model system.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v13.i1.91