Image-Based Three-Dimensional Analysis to Characterize the Texture of Porous Scaffolds

The aim of the present study is to characterize the microstructure of composite scaffolds for bone tissue regeneration containing different ratios of chitosan/gelatin blend and bioactive glasses. Starting from realistic 3D models of the scaffolds reconstructed from micro-CT images, the level of hete...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-8
Main Authors: Morbiducci, Umberto, Bignardi, Cristina, Ciardelli, Gianluca, Audenino, Alberto, Gallo, Diego, Gentile, Piergiorgio, Massai, Diana, Pennella, Francesco
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Biomedical materials
Bone Regeneration
Chitosan - chemistry
Chitosan - therapeutic use
Colleges & universities
Ecosystems
Humans
Imaging, Three-Dimensional
Materials
Mechanical properties
Osteogenesis
Porosity
Structure
Tissue Engineering
Tissue Scaffolds
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Summary:The aim of the present study is to characterize the microstructure of composite scaffolds for bone tissue regeneration containing different ratios of chitosan/gelatin blend and bioactive glasses. Starting from realistic 3D models of the scaffolds reconstructed from micro-CT images, the level of heterogeneity of scaffold architecture is evaluated performing a lacunarity analysis. The results demonstrate that the presence of the bioactive glass component affects not only macroscopic features such as porosity, but mainly scaffold microarchitecture giving rise to structural heterogeneity, which could have an impact on the local cell-scaffold interaction and scaffold performances. The adopted approach allows to investigate the scale-dependent pore distribution within the scaffold and the related structural heterogeneity features, providing a comprehensive characterization of the scaffold texture.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/161437