Perinatal hyperoxia exposure impairs hypoxia-induced depolarization in rat carotid body glomus cells

Highlights • Perinatal hyperoxia exposure markedly reduces rat carotid body glomus cell membrane depolarization in response to hypoxia. • Hyperoxia during development has little effect on glomus cell baseline electrophysiological characteristics. • Hyperoxia during development has no effect on glomu...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2013-08, Vol.188 (1), p.9-14
Main Authors: Kim, Insook, Yang, Dongjin, Carroll, John L, Donnelly, David F
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Carotid body
Carotid Body - cytology
Carotid Body - metabolism
Cell Hypoxia - physiology
Chemoreceptor
Development
Female
Hyperoxia - complications
Hyperoxia - metabolism
Male
Medical Education
Membrane Potentials - physiology
Oxygen sensing
Potassium channel
Pulmonary/Respiratory
Rats
Rats, Sprague-Dawley
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Summary:Highlights • Perinatal hyperoxia exposure markedly reduces rat carotid body glomus cell membrane depolarization in response to hypoxia. • Hyperoxia during development has little effect on glomus cell baseline electrophysiological characteristics. • Hyperoxia during development has no effect on glomus cell resting conductance normalized to cell size. • Impairment of carotid body function by perinatal hyperoxia is exposure appears to be due to a decreased hypoxia-induced depolarizing current.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2013.04.016