Luliconazole Demonstrates Potent In Vitro Activity against Dermatophytes Recovered from Patients with Onychomycosis

The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all i...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2014-06, Vol.58 (6), p.3553-3555
Main Authors: WIEDERHOLD, Nathan P, FOTHERGILL, Annette W, MCCARTHY, Dora I, TAVAKKOL, Amir
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents
Antifungal Agents - pharmacology
Arthrodermataceae
Arthrodermataceae - drug effects
Biological and medical sciences
Dermatomycoses
Dermatomycoses - complications
Dermatomycoses - drug therapy
Human mycoses
Humans
Imidazoles
Imidazoles - pharmacology
Infectious diseases
Medical sciences
Microbial Sensitivity Tests
Morpholines - pharmacology
Mycoses
Mycoses of the skin
Naphthalenes - pharmacology
Onychomycosis
Onychomycosis - complications
Onychomycosis - microbiology
Pharmacology. Drug treatments
Pyridones - pharmacology
Susceptibility
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Summary:The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02706-13