Molecular Epidemiology of KPC-Producing Escherichia coli: Occurrence of ST131-fimH30 Subclone Harboring pKpQIL-Like IncFIIk Plasmid

Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2014-07, Vol.58 (7), p.4234-4237
Main Authors: O'HARA, Jessica A, FUPIN HU, CHULSOO AHN, NELSON, Jeremy, RIVERA, Jesabel I, PASCULLE, Anthony W, YOHEI DOI
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins
Bacterial Proteins - genetics
beta-Lactamases
beta-Lactamases - genetics
Biological and medical sciences
Drug Resistance, Multiple, Bacterial
Drug Resistance, Multiple, Bacterial - genetics
Epidemiology and Surveillance
Escherichia coli
Escherichia coli - genetics
Escherichia coli Infections - drug therapy
Gentamicins - pharmacology
Humans
Klebsiella pneumoniae
Medical sciences
Microbial Sensitivity Tests
Molecular Epidemiology
Pharmacology. Drug treatments
Plasmids
Plasmids - genetics
Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology
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Summary:Of 20 Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for the blaKPC-carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Three blaKPC-carrying plasmids (IncA/C and IncN) possessed blaSHV-7/12 and qnrA1 or qnrS1.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02182-13