Changes of HMGB1 and sRAGE during the recovery of COPD exacerbation

Acute exacerbation of chronic obstructive pulmonary disease is associated with increased airway and systemic inflammation. However, the correlation between acute exacerbation/convalescence of chronic obstructive pulmonary disease (COPD) and simultaneous changes of high mobility group protein B1 (HMG...

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Published in:Journal of thoracic disease 2014-06, Vol.6 (6), p.734-741
Main Authors: Zhang, Yonghong, Li, Shaojun, Wang, Guizuo, Han, Dong, Xie, Xinming, Wu, Yuanyuan, Xu, Jing, Lu, Jiamei, Li, Fengjuan, Li, Manxiang
Format: Article
Language:English
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Summary:Acute exacerbation of chronic obstructive pulmonary disease is associated with increased airway and systemic inflammation. However, the correlation between acute exacerbation/convalescence of chronic obstructive pulmonary disease (COPD) and simultaneous changes of high mobility group protein B1 (HMGB1) and soluble RAGE (sRAGE) levels has not been clearly clarified. The aim of this study was to assess these issues. A total of 44 COPD patients were recruited. Following a structured interview, plasma levels of HMGB1, sRAGE, fibrinogen and serum level of high-sensitivity C-reactive protein (hsCRP) were measured in patients with acute exacerbation of COPD (AECOPD) within 24 h of hospitalization and pre-discharge (convalescence). All patients were examined with spirometry in convalescence of COPD. There was a significant decline in plasma HMGB1 (P
ISSN:2072-1439
2077-6624
DOI:10.3978/j.issn.2072-1439.2014.04.31