Mechanism of NLRP3 inflammasome activation

Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐associated molecular patterns into a proinflammatory response. This potent caspase‐1–dependent process is capable of activating...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2014-06, Vol.1319 (1), p.82-95
Main Authors: Sutterwala, Fayyaz S., Haasken, Stefanie, Cassel, Suzanne L.
Format: Article
Language:English
Subjects:
Activation
Adaptive Immunity - immunology
Adaptive systems
Animals
calcium
Carrier Proteins - metabolism
caspase-1
Cell death
Cell Death - immunology
Cell Survival - immunology
Damage
Humans
Immune system
Immune systems
Immunity
inflammasome
Inflammasomes - chemistry
Inflammasomes - physiology
mitochondria
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3
Priming
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Summary:Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐associated molecular patterns into a proinflammatory response. This potent caspase‐1–dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.12458