Influence of HBcAg in liver cell plasma on expression of transforming growth factor-beta 1 in liver tissue of low-grade chronic hepatitis B patients

• Published in: World journal of gastroenterology : WJG 2006-01, Vol.12 (1), p.127-129
• Main Authors: Liu, Yong-Gang, Lu, Jian-Hua, Wang, Xin-Xin, Yang, Jian-Lin, Lang, Zhen-Wei, Meng, Xin, Zhang, Li-Jie, Sun, Lin, Zhang, Shi-Jie, Li, Jun-Qiang, Song, Chen-Zhao
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Female; Hepatitis B Core Antigens - analysis; Hepatitis C, Chronic - metabolism; Humans; Immunohistochemistry; Liver - chemistry; Male; Middle Aged; Rapid Communication; Transforming Growth Factor beta - analysis; Transforming Growth Factor beta1; 慢性乙型肝炎; 等离子体; 肝细胞; 转化生长因子β1
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i1.127

AIM： To study the influence of HBcAg on the expression of transforming growth factor-beta 1 （TGF-131） in liver tissue of low-grade chronic hepatitis B （CHB） patients. METHODS： The expression of T（3F-β1 and HBcAg in liver samples from 93 low-grade CHB patients was detected by immunohistochemistry and valuated by semi-quantitative scoring. RESULTS： In the 93 low-grade CHB patients, HBcAg was expressed in cell plasma but not in the liver tissue. There was no significant difference between the two groups. CONCLUSION： The expression of TGF-β1 is not related with HBcAg expressed as plasma type in the tissues of low-grade CHB patients.