Peroxisome proliferator-activated receptor α,a potential therapeutic target for alcoholic liver disease

• Published in: World journal of gastroenterology : WJG 2014-07, Vol.20 (25), p.8055-8060
• Main Authors: Nan, Yue-Min, Wang, Rong-Qi, Fu, Na
• Format: Article
• Language: English
• Subjects: Alcoholic; Animals; Anti-Inflammatory Agents - therapeutic use; Antioxidants - therapeutic use; disease; Drug Design; Humans; Inflammat; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; Lipid Metabolism - drug effects; Lipid Peroxidation - drug effects; liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver Diseases, Alcoholic - drug therapy; Liver Diseases, Alcoholic - metabolism; Liver Diseases, Alcoholic - pathology; Molecular Targeted Therapy; Oxidative; Oxidative Stress - drug effects; PPAR alpha - agonists; PPAR alpha - metabolism; Signal Transduction - drug effects; stress; Topic Highlight
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v20.i25.8055

Alcoholic liver injury represents a progressive process with a range of consequences including hepatic steatosis, steatohepatitis, liver fibrosis, cirrhosis, and hepatocellular carcinoma. Targeting key molecular regulators involved in the development of alcoholic liver injury may be of great value in the prevention of liver injury. Peroxisome proliferator-activated receptor α(PPARα) plays a pivotal role in modulation of hepatic lipid metabolism, oxidative stress, inflammatory response and fibrogenesis. As such, PPARα may be a potential therapeutic target for the treatment of alcoholic liver disease.